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von Willebrand factor propolypeptide

Also Known As:

Pro-vWf; pro-von Willebrand factor

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - von Willebrand Factor: 6708
        von Willebrand factor propolypeptide: 3
  - Protein Precursors: 37
    - von Willebrand factor propolypeptide: 3
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - von Willebrand Factor: 6708
    - von Willebrand factor propolypeptide: 3

Experts

1.	Binder, B: 1 article (03/2000)
2.	Denis, C: 1 article (03/2000)
3.	Dorner, F: 1 article (03/2000)
4.	Lenting, P J: 1 article (03/2000)
5.	Mihaly, J: 1 article (03/2000)
6.	Schwarz, H P: 1 article (03/2000)
7.	Turecek, P L: 1 article (03/2000)

Related Diseases

1.	von Willebrand Diseases (von Willebrand's Disease) 09/01/1999 - "A recombinant preparation (rpvWF) containing both pro-vWF and mature vWF subunits was infused into 2 pigs and 1 dog with severe von Willebrand disease, 2 mice with a targeted disruption of the vWF gene, and 2 healthy baboons. " 09/01/1999 - "Evidence for extracellular processing of pro-von Willebrand factor after infusion in animals with and without severe von Willebrand disease." 03/01/2000 - "We used a murine model of severe von Willebrand disease (vWF knockout mice) to study the effect of a recombinant vWF/pro-vWF preparation (rpvWF) on factor VIII survival and to investigate whether low-density lipoprotein receptor-related protein (LRP) might be involved in the in vivo clearance of factor VIII in the absence of vWF. "
2.	Vaccinia 03/01/1995 - "The cleavage of pro-vWF by Dfurin2 shows that the previously reported lack of cleavage of the precursor of the beta A-chain of activin-A by Dfurin2 in this vaccinia expression system is substrate determined." 03/01/1995 - "In a vaccinia expression system, the endoprotease Dfurin2 not only cleaved wild-type precursor of von Willebrand factor (pro-vWF) with pro-region cleavage site R-S-K-R decreases, but also, although to a lesser extent, pro-vWF mutants in which the P2 (vWFK-2A) or P4 (vWFR-4A) basic residue with respect to the pro-region cleavage site had been mutated. "

Related Drugs and Biologics

1.	LDL Receptors (LDL Receptor)
2.	Proteins (Proteins, Gene)
3.	Factor VIII (Coagulation Factor VIII)
4.	von Willebrand Factor
5.	activin A
6.	dfurin2