|1.||Santini, Donatella: 3 articles (01/2015 - 03/2007)|
|2.||Taffurelli, Mario: 3 articles (01/2015 - 03/2007)|
|3.||Storci, Gianluca: 3 articles (11/2010 - 03/2007)|
|4.||Sansone, Pasquale: 3 articles (11/2010 - 03/2007)|
|5.||Sarkar, Fazlul H: 3 articles (03/2010 - 11/2006)|
|6.||Wang, Zhiwei: 3 articles (03/2010 - 11/2006)|
|7.||Banerjee, Sanjeev: 3 articles (03/2010 - 11/2006)|
|8.||Li, Yiwei: 3 articles (03/2010 - 11/2006)|
|9.||Bonafè, Massimiliano: 2 articles (01/2015 - 11/2010)|
|10.||Pintar, Alessandro: 2 articles (03/2013 - 11/2009)|
01/01/2015 - "The current study suggests that MSC-mediated immune modulation involves the education and expansion of regulatory immune cells in a Jagged-1 dependent manner and provides the first report of the importance of Jagged-1 signalling in MSC protection against inflammation in vivo."
01/01/2015 - "MSC, but not Jagged-1 knock down MSC, reduced pathology in a mouse model of allergic airway inflammation. "
03/15/2009 - "The present study shows that Notch-2 and its ligand, Jagged-1, are highly up-regulated in GR cells, which is consistent with the role of the Notch signaling pathway in the acquisition of EMT and cancer stem-like cell phenotype. "
11/01/2011 - "Notch signaling affects tumor growth and angiogenesis through the actions of its ligand Jagged-1. "
12/01/2010 - "High levels of Jagged-1 are a common feature of ovarian tumors. "
11/01/2010 - "Patients harboring tumors with both high-level Jagged-1 (J1(Hi)) and high-level Notch-1 (N1(Hi)) had a worse overall survival than the patients only with J1(Hi) or N1(Hi) as well as the patients with low-level Jagged-1 and Notch-1 (J1(Lo)/N1(Lo)) (P < 0.001). "
12/01/2008 - "The growth of intracranial tumors was also associated with decreased levels of HO-1, a mediator of anti-apoptotic function, and increased levels of Notch-1 and its ligand, Jagged-1. "
|3.||Breast Neoplasms (Breast Cancer)
06/29/2012 - "Elevated levels of Jagged-1 (JAG1), a predicted miR-21 target, are implicated in estrogen receptor negative (ER-) breast cancer. "
11/01/2010 - "Moreover, SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness. "
07/01/2008 - "High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. "
03/01/2007 - "Because Notch-3, Jagged-1, and carbonic anhydrase IX are dysregulated in breast cancer, and because p66Shc is an aging-regulating gene, we envision that these data may help in understanding the relationship among aging, cancer, and stem cells."
01/01/2011 - "In this study, we identified one such estrogen downregulated miRNA, miR-34b, as an oncosuppressor that targets cyclin D1 and Jagged-1 (JAG1) in an ER+/wild-type p53 breast cancer cell line (MCF-7), as well as in ovarian and endometrial cells, but not in ER-negative or mutant p53 breast cancer cell lines (T47D, MBA-MB-361 and MDA-MB-435). "
|4.||Prostatic Neoplasms (Prostate Cancer)
11/01/2006 - "Hence, the aim of our current study was to investigate the mechanistic role of Jagged-1 in prostate cancer cell growth and cell cycle progression. "
01/01/2013 - "Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers."
03/01/2010 - "Likewise, Notch ligand Jagged-1 was found to be over-expressed in metastatic prostate cancer compared to localized prostate cancer or benign prostatic tissues, suggesting the biological significance of Notch signaling in prostate cancer progression. "
11/01/2006 - "These results suggest that Jagged-1 could be a potential therapeutic target for the treatment of prostate cancer."
11/01/2006 - "Therefore, deregulation of Jagged-1 protein levels may play a role in prostate cancer cell growth and progression. "
|5.||Neoplasm Metastasis (Metastasis)
01/01/2013 - "Our results provide strong evidence that up-regulation of Jagged1-Notch1 signaling plays a role in PCa progression and metastasis and suggest that Jagged-1 and Notch-1 may be useful markers in distinguishing indolent and aggressive PCas."
01/01/2013 - "In the present study, we investigated the expression levels of Jagged-1 and Notch-1 in human prostate tumors and their associations with PCa progression and metastasis. "
10/01/2004 - "These findings support a model in which dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers."
|1.||Messenger RNA (mRNA)
|3.||Transcription Factors (Transcription Factor)
|7.||Amyloid Precursor Protein Secretases (beta-Secretase)
|8.||Small Interfering RNA (siRNA)
|9.||Interleukin-6 (Interleukin 6)
|10.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)