Clk dual-specificity kinases

a dual specificity kinase of the LAMMER kinase family; from embryonal carcinoma cell line; amino acid sequence given in first source

Also Known As:

CDC-like kinase 1; CDC-like kinase 1 protein, mouse; CDC-like kinase 1, human; CDC-like kinase 2; CDC-like kinase 2 protein, human; CDC-like kinase 3; CDC-like kinase 3, human; CDC-like kinase 3, rat; CDC-like kinase 4; CLK1 kinase; CLK1 protein, human; CLK2 kinase; CLK4 kinase; Clk kinase; Clk1 protein, mouse; Clk3 kinase; Clk3 protein, rat; STY kinase; STY kinase, mouse; clk2 protein, human; clk3 protein, human; hclk2 protein, human; rat Clk3

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hochberg, Marc C: 2 articles (12/2020 - 10/2020)
2.	Chen, Zhuo: 1 article (05/2022)
3.	Li, Yun-Xiao: 1 article (05/2022)
4.	Liu, Shi-Fang: 1 article (05/2022)
5.	Wei, Yong-Chang: 1 article (05/2022)
6.	Xu, Xin-Hua: 1 article (05/2022)
7.	Yang, Li: 1 article (05/2022)
8.	Yuan, Jin-Hua: 1 article (05/2022)
9.	Zhou, Hai-Bo: 1 article (05/2022)
10.	Chang, Zhengyan: 1 article (01/2022)

Related Diseases

1.	Knee Osteoarthritis 10/01/2020 - "Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial."
2.	Squamous Cell Carcinoma of Head and Neck 01/01/2022 - "This study aimed to explore the role of circular-CDC like kinase 1 (circ-CLK1) in the pathogenesis of oral squamous cell carcinoma (OSCC). " 01/01/2022 - "Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma."
3.	Inflammation (Inflammations) 01/01/2022 - "Bioinformatics analysis showed that the structure of chicken PPDPF evolutionarily conserved amino acid sequences with domains, i.e., SH3 binding sites and CDC-like kinase 2 (CLK2) binding sites, suggesting that relevant signaling pathways might contribute to suppression of inflammation. " 12/01/2020 - "It modulates the Wnt signaling pathway by inhibiting CDC-like kinase 2 and dual-specificity tyrosine phosphorylation-regulated kinase 1 A which are molecular regulators in Wnt signaling, chondrogenesis, and inflammation. "
4.	Cholangiocarcinoma 01/01/2020 - "Herein, we demonstrated that CLK3 was significantly up-regulated in cholangiocarcinoma (CCA) and identified a recurrent Q607R somatic substitution that represented a gain-of-function mutation in the CLK3 kinase domain. "
5.	Colorectal Neoplasms (Colorectal Cancer) 05/01/2022 - "CDC Like Kinase 2 plays an oncogenic role in colorectal cancer via modulating the Wnt/β-catenin signaling."

Related Drugs and Biologics

1.	Dyrk Kinases
2.	lorecivivint
3.	Proteins (Proteins, Gene)
4.	Catenins
5.	Tyrosine (L-Tyrosine)
6.	RNA Precursors (Precursor, mRNA)
7.	Phosphotransferases (Kinase)
8.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)