virus activating protease

endoprotease from chick embryo; activates para- and orthomyoxovirus fusion glycoproteins by cleaving them at a single arginine site; Ca(2+) dependent; similar to blood clotting factor X

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abdelwhab, Elsayed M: 1 article (01/2021)
2.	Bestle, Dorothea: 1 article (01/2021)
3.	Böttcher-Friebertshäuser, Eva: 1 article (01/2021)
4.	Harbig, Anne: 1 article (01/2021)
5.	Kruhl, Diana: 1 article (01/2021)
6.	Limburg, Hannah: 1 article (01/2021)
7.	Matrosovich, Mikhail: 1 article (01/2021)
8.	Moulton, Hong: 1 article (01/2021)
9.	Stech, Jürgen: 1 article (01/2021)
10.	Stein, David A: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2010 - "Here we demonstrate that the malignant colon cancer cell lines Caco-2, HT-29 and SW-620 can endogenously provide a virus-activating protease, which allows lytic multi-cycle replication of NS1 deletion viruses in those cancer cells in vitro. "
2.	Infections 07/01/2013 - "The intracellular cleavage HA0-->HA1+HA2 by the host virus-activating protease (IAP) occurred in both human cell lines under infection with each influenza virus H1N1 including pandemic ones. "
3.	Influenza in Birds (Avian Flu) 01/01/2021 - "Additionally, we show that a TMPRSS2-orthologous protease from duck can activate avian influenza virus HAs with a monobasic cleavage site and, thus, represents a potential virus-activating protease in waterfowl, the primary reservoir for influenza A viruses."
4.	Colonic Neoplasms (Colon Cancer) 09/15/2010 - "Here we demonstrate that the malignant colon cancer cell lines Caco-2, HT-29 and SW-620 can endogenously provide a virus-activating protease, which allows lytic multi-cycle replication of NS1 deletion viruses in those cancer cells in vitro. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)