|1.||Norman, Andrew B: 1 article (12/2014)|
|2.||Ball, William J: 1 article (12/2014)|
|3.||Tabet, Michael R: 1 article (12/2014)|
|4.||Wetzel, Hanna N: 1 article (12/2014)|
|5.||Hou, Shurong: 1 article (06/2014)|
|6.||Zhan, Chang-Guo: 1 article (06/2014)|
|7.||Zhan, Max: 1 article (06/2014)|
|8.||Zheng, Xirong: 1 article (06/2014)|
|9.||Zheng, Fang: 1 article (06/2014)|
|10.||Subramanian, Ramanand A: 1 article (11/2010)|
|1.||Alcoholism (Alcohol Abuse)
07/01/1995 - "These findings suggest that cocaethylene may play a role in the morbidity and mortality associated with concurrent cocaine/alcohol abuse. "
12/01/2014 - "The ability of h2E2 to protect the brain from both cocaine and cocaethylene predicts that the clinical efficacy of h2E2 will be retained in cocaine users who co-abuse alcohol."
12/01/2014 - "However, many cocaine users co-abuse alcohol, leading to the formation of the centrally active metabolite cocaethylene. "
|2.||Cocaine-Related Disorders (Cocaine Addiction)
09/01/1999 - "The relevance of these data for the use of cocaethylene as a model compound for an agonist approach to therapy for cocaine dependence is discussed."
09/01/1999 - "Rapid induction of behavioral and neurochemical tolerance to cocaethylene, a model compound for agonist therapy of cocaine dependence."
01/23/2004 - "Cocaethylene is a naturally occurring cocaine derivative that has been used as a tool in both clinical studies of cocaine reward and as a potential model compound for agonist substitution therapy in cocaine dependence. "
09/01/1999 - "Cocaethylene, a psychoactive metabolite resulting from concurrent alcohol and cocaine consumption, was examined because of its use in human research studies of drug reward mechanisms, and its potential as a model compound for an agonist based therapy for cocaine dependence. "
06/15/2014 - "Hence a truly valuable cocaine-metabolizing enzyme as treatment for cocaine abuse/overdose should be efficient for not only cocaine itself, but also cocaethylene. "
06/18/1997 - "For the neurochemistry study, five groups of artificially reared pups were used and were treated identically to those in the brain growth restrictions study, with the exceptions that animals assigned to acute cocaethylene treatment groups did not receive cocaethylene from PDs 4 through 8 and all animals in this study were sacrificed on PD 9 by decapitation. "
01/01/1997 - "However, cocaethylene has been associated with seizures, liver damage, and compromised functioning of the immune system. "
06/01/1996 - "A similar increase in seizure prevalence, noted as a kindling effect, was observed in cocaethylene-treated animals tested with cocaethylene in that 90% of the mice exhibited status epilepticus on the last test day. "
06/01/1996 - "Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine."
01/01/1995 - "4. Thus, both cocaine and cocaethylene may produce their lethal effects in mice through neuro-regulatory mechanisms mediating protracted seizure induction."
01/01/1992 - "In contrast to the behavioral effects, cocaine and cocaethylene were equipotent in producing convulsions, and cocaethylene was more potent than cocaine in producing lethality. "
|5.||Wounds and Injuries (Trauma)
11/01/2010 - "Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma."
03/01/1996 - "To determine the presence of cocaethylene, an active metabolite of the combination of cocaine and ethanol, among trauma patients who test positive for cocaine. "
03/01/1993 - "Cocaethylene (EC), cocaine (COC), and ethanol (ETOH) concentrations were measured in 46 serial plasma samples from 15 male trauma victims. "
03/01/1993 - "Serial plasma concentrations of cocaethylene, cocaine, and ethanol in trauma victims."
|1.||Cocaine (Cocaine HCl)
|3.||Ethanol (Ethyl Alcohol)
|5.||Street Drugs (Illicit Drugs)
|7.||Morphine (MS Contin)
|10.||Codeine (Codeine Phosphate)