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phospholipid-hydroperoxide glutathione peroxidase

selenoenzyme found in biological materials; a protein thiol peroxidase; different from glutathione peroxidase EC 1.11.1.9
Also Known As:
GPX4 glutathione peroxidase; PH-GPeroxidase; PHGPx enzyme; glutathione peroxidase 4; glutathione peroxidase GPX4; selenium-dependent glutathione peroxidase type-4
Networked: 59 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Lin, Chunmei: 4 articles (12/2015 - 11/2012)
2. Nam, Sang-Yoon: 4 articles (12/2015 - 11/2012)
3. Yon, Jung-Min: 4 articles (12/2015 - 11/2012)
4. Baek, In-Jeoung: 3 articles (12/2015 - 04/2014)
5. Yun, Young Won: 3 articles (11/2015 - 11/2012)
6. Lee, Beom Jun: 3 articles (11/2015 - 11/2012)
7. Conrad, Marcus: 3 articles (08/2013 - 09/2009)
8. Schneider, Manuela: 3 articles (08/2013 - 09/2009)
9. Huang, Huei-Sheng: 3 articles (09/2003 - 09/2002)
10. Ran, Qitao: 2 articles (11/2015 - 01/2009)

Related Diseases

1. Anoxia (Hypoxia)
05/01/2014 - "In this study, hypoxia is identified as a powerful stimulus to redirect selenoprotein biosynthesis causing reduced selenoprotein P expression and diminished selenium export from hepatocytes in favour of increased biosynthesis of the essential protective intracellular phospholipid hydroperoxide glutathione peroxidase GPX4. "
04/01/2014 - "Embryos exposed to 1 mM nicotine developed not only severe morphological anomalies, increased expressions of tumor necrosis factor-α, interleukin-1β, and caspase 3 mRNAs; and elevated levels of lipid peroxidation, but also decreased levels of cytoplasmic superoxide dismutase, cytosolic glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, hypoxia inducible factor-1α, and B-cell lymphoma-extra large mRNAs, and reduced superoxide dismutase activity. "
08/01/2006 - "The transcript levels of three genes coding for antioxidants, Cu/Zn superoxide dismutase (SOD), catalase and phospholipid hydroperoxide glutathione peroxidase (GSH-Px), and those of two stress proteins, metallothionein (MT) and CYP1A, were examined with real-time quantitative (q) RT-PCR in hepatic tissue of Atlantic cod exposed to 46% (hypoxia), 76% (normoxia) and 145% (hyperoxia) O(2) saturation (tank outlet). "
11/01/2012 - "Embryos exposed to nicotine (1mM) revealed significantly severe morphological anomalies, increased levels of caspase-3 mRNA and lipid peroxidation, and decreased levels of cytoplasmic superoxide dismutase (SOD), mitochondrial manganese SOD, cytosolic glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, hypoxia-inducible factor 1α, Bcl-x(L), and sirtuin1 (SIRT1) mRNAs and SOD activity compared to those in the normal control group. "
2. Male Infertility (Male Sterility)
3. Neoplasms (Cancer)
4. Squamous Cell Carcinoma (Epidermoid Carcinoma)
5. Hepatocellular Carcinoma (Hepatoma)

Related Drugs and Biologics

1. Selenium
2. Selenoproteins (Selenoprotein)
3. Selenoprotein P
4. Glutathione Peroxidase
5. Messenger RNA (mRNA)
6. Superoxide Dismutase
7. Caspase 3 (Caspase-3)
8. Reactive Oxygen Species (Oxygen Radicals)
9. Selenocysteine
10. Oxidoreductases

Related Therapies and Procedures

1. Lasers (Laser)