O- (5- O- (4- coumaroyl)- alpha- arabinofuranosyl)- (1- 3)- O- beta- xylopyranosyl- (1- 4)- xylopyranose

from bamboo shoot cell-wall; structure and properties given in first source

Also Known As:

4-coumaroyl arabinoxylan; O-(5-O-(trans-4-coumaroyl)-alpha-L-arabinofuranosyl)-(1-3)-O-beta-D-xylopyranosyl-(1-4)-D-xylopyranose; PAXX

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Trisaccharides: 123
      - O-(5-O-(4-coumaroyl)-alpha-arabinofuranosyl)-(1-3)-O-beta-xylopyranosyl-(1-4)-xylopyranose: 16

Experts

1.	Oksenych, Valentyn: 4 articles (12/2020 - 01/2017)
2.	Xing, Mengtan: 3 articles (01/2019 - 01/2017)
3.	Liu, Xiangyu: 2 articles (01/2022 - 01/2017)
4.	Castañeda-Zegarra, Sergio: 2 articles (12/2020 - 01/2019)
5.	Gago-Fuentes, Raquel: 2 articles (01/2019 - 01/2018)
6.	Sæterstad, Siri: 2 articles (01/2019 - 01/2018)
7.	Bjørås, Magnar: 2 articles (01/2018 - 01/2017)
8.	Lee, Brian J: 2 articles (01/2018 - 01/2017)
9.	Zha, Shan: 2 articles (01/2018 - 01/2017)
10.	Balmus, Gabriel: 2 articles (11/2017 - 10/2016)

Related Diseases

1.	Infections 11/16/2017 - "Counterintuitively, PAXX-/- cells were able to produce greater numbers of infectious virions, indicating that PAXX acts to restrict HSV-1 infection in a manner that is different from other c-NHEJ factors." 11/16/2017 - "Here, we have investigated the role of the recently-discovered c-NHEJ component, PAXX (Paralogue of XRCC4 and XLF), which we found to be excluded from the nucleus during HSV-1 infection. " 11/16/2017 - "The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection." 01/01/2021 - "Recent studies have added a number of new proteins to the NHEJ repertoire namely paralog of XRCC4 and XLF (PAXX), modulator of retroviral infection (MRI)/ cell cycle regulator of NHEJ (CYREN), transactivation response DNA-binding protein (TARDBP) of 43 kDa (TDP-43), intermediate filament family orphan (IFFO1), ERCC excision repair 6 like 2 (ERCC6L2), and RNase H2. "
2.	Genomic Instability 01/01/2017 - "As such, Xlf-/-Paxx-/- mice display severe genomic instability and neuronal apoptosis, which eventually lead to embryonic lethality. " 10/01/2016 - "Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4-/- and Lig4-/- mice. " 01/01/2019 - "Inactivation of Ku70 or Ku80 genes in mice results in immunodeficiency and high levels of genomic instability; deletion of individual Dna-pkcs, Xlf, Paxx or Mri genes results in viable mice with no or modest DNA repair defects. " 01/01/2017 - "In the absence of core C-NHEJ factors, DNA repair can be performed by Alternative End-Joining, which likely depends on DNA Ligase 1 and DNA Ligase 3. Genetic inactivation of C-NHEJ factors, such as Ku70, Ku80, XLF, PAXX and DNA-PKcs results in viable mice showing increased levels of genomic instability and sensitivity to DSBs. "
3.	Neoplasms (Cancer) 01/01/2022 - "This review will summarize and discuss the function of PAXX in DSBs repair and its potential role in cancer development." 01/01/2020 - "We also observed hypomethylation of PAXX promoter in tumors, which exhibited a strong correlation with its overexpression. " 01/01/2022 - "Emerging evidence also shows a connection between the expression levels of PAXX and cancer development in human patients, indicating a prognosis role of the protein. "
4.	Carcinogenesis 05/01/2023 - "Mechanisms of this combined carcinogenesis may include promotion of cell proliferation, perturbation of the cell cycle, promotion of invasiveness, DNA double-strand break induction, or PAXX inhibition."
5.	Microsatellite Instability 01/01/2020 - "We performed a comprehensive analysis of seven essential genes, including XRCC5, XRCC6, PRKDC, LIG4, XRCC4, NHEJ1, and PAXX of this pathway, in colon cancer using multi-omics datasets, and studied their associations with molecular and clinicopathological features, including age, gender, stage, KRAS mutation, BRAF mutation, microsatellite instability status and promoter DNA methylation in TCGA colon cancer dataset. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Ribonucleases (Ribonuclease)
3.	DNA-Binding Proteins (DNA Binding Protein)
4.	DNA (Deoxyribonucleic Acid)
5.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
6.	Therapeutic Uses
7.	DNA Ligases (Ligases, DNA)
8.	Phosphotransferases (Kinase)
9.	Doxorubicin (Adriamycin)
10.	Cisplatin (Platino)