vintoperol

structure given in first source; no information given that it is a vinca alkaloid; RN refers to (3alpha, 16alpha)-isomer; RN for compound without isomeric designation not available 12/90

Also Known As:

1 beta-ethyl-indolo(2,3-a)naphthyridin-1 alpha-yl-methanol; 1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine-1-methanol; RGH 2981; RGH-2981; RT 3003; RT-3003

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - vintoperol: 3
    - Quinolizines: 1
      - vintoperol: 3

Related Diseases

1.	Stupor 05/01/1992 - "The effects of vintoperol have been studied in the experiments on the vascular bed of femoral artery of 15 mongrel dogs under chlorazol-urethane narcosis and on isolated vascular preparations of rats. "
2.	Thrombosis (Thrombus) 01/01/1994 - "Results of these experiments indicate that vintoperol interferes with platelet aggregation both in vitro and in vivo and possesses potent antithrombotic effects in thrombosis models in which platelet activation is mainly involved." 01/01/1994 - "Effect of vintoperol on platelet aggregation and experimental thrombosis."
3.	Sudden Death 01/01/1994 - "Sudden death of mice evoked by hardened red blood cell suspension was not protected by vintoperol. "
4.	Vascular Ring 01/01/1992 - "Vintoperol-induced relaxation of vascular rings was also inhibited by gossypol (2 x 10(-5) M) or methylene blue (5 x 10(-5) M); the level of inhibition (50-100%) or methylene blue (5 x 10(-5) M); the level of inhibition (50-100%) depended on the duration of exposure to the inhibitors. "

Related Drugs and Biologics

1.	Urethane (Ethyl Carbamate)
2.	Suspensions
3.	Methylene Blue (Methylthioninium Chloride)
4.	Gossypol