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5'- S- (2- aminoethyl)- N(6)- (4- nitrobenzyl)- 5'- thioadenosine

structure given in first source

Also Known As:

SAENTA

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Barron, Geraldine: 1 article (08/2010)
2.	Cass, Carol E: 1 article (08/2010)
3.	Damaraju, Vijaya L: 1 article (08/2010)
4.	Mowles, Delores: 1 article (08/2010)
5.	Peng, Yunshan: 1 article (08/2010)
6.	Robins, Morris J: 1 article (08/2010)
7.	Tackaberry, Tracey: 1 article (08/2010)
8.	Young, James D: 1 article (08/2010)
9.	Dinger, Cornelia: 1 article (09/2009)
10.	Glatting, Gerhard: 1 article (09/2009)

Related Diseases

1.	Leukemia 09/01/2009 - "Three new potential hENT(1) inhibitors suitable for labeling with PET/SPECT radioisotopes were prepared from an advanced intermediate 4. They were tested for their capability to inhibit binding of SAENTA-fluorescein to HL60 leukemia cells in flow cytometry assay and SAENTA-I (5) was determined to be the most active compound. " 07/01/1997 - "Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein."
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/01/1998 - "The cellular content of es transporter sites has been measured in blasts from patients with acute lymphoblastic leukemia and acute myelogenous leukemia, by a sensitive, quantitative flow cytometry assay that employs the tightly-bound es ligand, SAENTA fluorescein. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/1998 - "The cellular content of es transporter sites has been measured in blasts from patients with acute lymphoblastic leukemia and acute myelogenous leukemia, by a sensitive, quantitative flow cytometry assay that employs the tightly-bound es ligand, SAENTA fluorescein. "
4.	Neoplasms (Cancer) 08/26/2010 - "Conjugation of the pendant amino groups of SAENTA and SAHENTA with fluorescein-5-yl isothiocyanate (FITC) gave fluorescent probes that bound at nanomolar concentrations specifically to human equilibrative nucleoside transporter 1 (hENT1) produced in recombinant form in model expression systems and in native form in cancer cell lines. "

Related Drugs and Biologics

1.	Fluorescein (Funduscein)
2.	Equilibrative Nucleoside Transporter 1
3.	Nucleoside Transport Proteins (Nucleoside Transporter)
4.	Fluorescein-5-isothiocyanate (FITC)
5.	Radioisotopes (Radionuclides)
6.	Ligands
7.	Fluorescent Dyes (Fluorescent Probes)
8.	Cytarabine (Cytosar-U)
9.	isothiocyanic acid