tingenin B

isolated from Glyptopetalum sclerocarpaum; structure given in first source; RN given refers to (20beta,22beta)-isomer; RN for cpd without isomeric designation not available 11/90; RN is for tingenin A (8/2001)

Also Known As:

22-hydroxytingenone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - tingenin B: 2

Experts

1.	Bezerra, Daniel P: 1 article (10/2021)
2.	Bomfim, Larissa M: 1 article (10/2021)
3.	Costa, Emmanoel V: 1 article (10/2021)
4.	Dias, Rosane B: 1 article (10/2021)
5.	Koolen, Hector H F: 1 article (10/2021)
6.	Neves, Sara P: 1 article (10/2021)
7.	Rocha, Clarissa A Gurgel: 1 article (10/2021)
8.	Rocha, Waldireny C: 1 article (10/2021)
9.	Rodrigues, Ana Carolina B da C: 1 article (10/2021)
10.	Soares, Milena B P: 1 article (10/2021)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/01/2021 - "Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells."
2.	Neoplasms (Cancer) 10/01/2021 - "Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes found in the Amazonian plant Salacia impressifolia (Celastraceae), with cytotoxic properties in different histological types of cancer cells. "
3.	Breast Neoplasms (Breast Cancer) 12/25/2016 - "The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro."

Related Drugs and Biologics

1.	Triterpenes
2.	Thioredoxins
3.	DNA (Deoxyribonucleic Acid)
4.	Antineoplastic Agents (Antineoplastics)
5.	tingenone