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3-hydroxy-10,11-dihydroquinidine
structure given in first source
Also Known As:
LNC 834; LNC-834; Cinchonan-3,9-diol, 10,11-dihydro-6'-methoxy-, (9S)-, sulfate (1:1) (salt)
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Cinchona Alkaloids: 29
Quinidine: 1737
3-hydroxy-10,11-dihydroquinidine: 1
Bridged-Ring Heterocyclic Compounds
Quinuclidines: 20
Quinidine: 1737
3-hydroxy-10,11-dihydroquinidine: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Quinidine: 1737
3-hydroxy-10,11-dihydroquinidine: 1
Related Diseases
1.
Ventricular Tachycardia
09/01/1990 - "
In the PES model, LNC-834 (3 mg of base/kg) suppressed ventricular tachycardia (VT) in 33% (2/6) of the dogs tested: none of the six quinidine-treated animals displayed suppression of VT at cumulative doses of 0.3 to 30 mg of base/kg. In PES dogs, inducible and noninducible, mortality was less with LNC-834 treatment than with quinidine [9% (1/11) and 36% (4/11), respectively].
"
2.
Ventricular Fibrillation
09/01/1990 - "
The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias.
"
3.
Infarction (Infarctions)
09/01/1990 - "
The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias.
"
4.
Hypotension (Low Blood Pressure)
09/01/1990 - "
Although no treatment significantly affected the intrinsic heart rate in VFT dogs, both LNC-834 and quinidine produced significant hypotension; however, LNC-834 caused less hypotension than did quinidine at equal doses.
"
5.
Cardiac Arrhythmias (Arrythmia)
09/01/1990 - "
Comparison of the effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine in canine models of arrhythmia.
"
09/01/1990 - "
The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias.
"
Related Drugs and Biologics
1.
Quinidine (Chinidin)