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himastatin

structure given in first source; isolated from cultured broth of Streptomyces hygroscopious

Also Known As:

Antibiotic BMY 40800

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - himastatin: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - himastatin: 2

Related Diseases

1.	Experimental Melanoma 08/01/1990 - "Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells." 11/01/1994 - "Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. "
2.	Leukemia P388 08/01/1990 - "Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells." 11/01/1994 - "Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. "
3.	Neoplasms (Cancer) 11/01/1994 - "The results also suggest that the cancer cytotoxic and antimicrobial effects of himastatin may result from interactions with the cell membrane."
4.	Colonic Neoplasms (Colon Cancer) 11/01/1994 - "Importantly, the activity of himastatin against HCT-116 colon adenocarcinoma cells in soft agar was markedly reduced in the presence of sodium palmitate as the reference fatty acid salt. "

Related Drugs and Biologics

1.	Palmitic Acid (Hexadecanoic Acid)
2.	Salts
3.	Fatty Acids (Saturated Fatty Acids)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Agar