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phthoxazolin

structure given in first source; isolated from Streptomyces

Also Known As:

phthoxazolin A; 4,6,8-Decatrienamide, 3-hydroxy-2,2,4-trimethyl-10-(5-oxazolyl)-, (Z,Z,E)-(+)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ikeda, Daishiro: 2 articles (01/2009 - 05/2004)
2.	Kawada, Manabu: 2 articles (01/2009 - 05/2004)
3.	Inoue, Hiroyuki: 1 article (01/2009)
4.	Usami, Ihomi: 1 article (01/2009)
5.	Ishizuka, Masaaki: 1 article (05/2004)
6.	Kumagai, Hiroyuki: 1 article (05/2004)
7.	Masuda, Tohru: 1 article (05/2004)
8.	Minamiguchi, Kazuhisa: 1 article (05/2004)
9.	Someno, Tetsuya: 1 article (05/2004)
10.	Yoshimoto, Yuya: 1 article (05/2004)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2009 - "Phthoxazolin A inhibits prostate cancer growth by modulating tumor-stromal cell interactions." 01/01/2009 - "Using an in vitro coculture system, in which prostate cancer cell growth is upregulated by prostate stromal cells (PrSC), we found that phthoxazolin A and inthomycin B strongly inhibited the growth of DU-145 cells when in coculture with PrSC compared to DU-145 cells cultured alone. " 01/01/2009 - "Taken together, our results suggested that phthoxazolin A acts as a small-molecule modulator of tumor-stromal cell interactions that can indirectly suppress prostate cancer cell growth through inhibition of IGF-I production by PrSC." 01/01/2009 - "Here, we report that phthoxazolin A and its analog inthomycin B inhibit the growth of human prostate cancer DU-145 cells by modulating tumor-stromal cell interactions. " 05/01/2004 - "As a result, we found that 5-fluorouracil, bleomycin and phthoxazolin A inhibit prostate cancer cell growth more strongly in coculture with PrSC than that in monoculture. "
2.	Neoplasms (Cancer) 01/01/2009 - "Phthoxazolin A inhibits prostate cancer growth by modulating tumor-stromal cell interactions." 01/01/2009 - "Taken together, our results suggested that phthoxazolin A acts as a small-molecule modulator of tumor-stromal cell interactions that can indirectly suppress prostate cancer cell growth through inhibition of IGF-I production by PrSC." 01/01/2009 - "Here, we report that phthoxazolin A and its analog inthomycin B inhibit the growth of human prostate cancer DU-145 cells by modulating tumor-stromal cell interactions. "

Related Drugs and Biologics

1.	Insulin-Like Growth Factor I (IGF-1)
2.	Fluorouracil (Carac)
3.	Bleomycin (Blenoxane)
4.	inthomycin B