NB 598

decreases serum total & LDL-cholesterol levels; structure given in first source; inhibits squalene epoxidase

Also Known As:

N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-((3,3'-bithiophen-5-yl)methoxy)benzenemethanamine; NB-598; Benzenemethanamine, 3-((3,3'-bithiophen)-5-ylmethoxy)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-ethyl-, (E)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chugh, Anita: 1 article (01/2003)
2.	Gupta, Jung B: 1 article (01/2003)
3.	Ray, Abhijit: 1 article (01/2003)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/15/1991 - "In the present study, the effects of NB-598 on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and low-density-lipoprotein (LDL) receptor were examined using a human hepatoma cell line Hep G2. "
2.	Dermatitis 01/01/2003 - "In dogs, NB-598, a potent competitive squalene epoxidase inhibitor has been reported to exhibit signs of dermatitis like toxicity which has been attributed by some reviewers to accumulation of squalene in skin cells. "

Related Drugs and Biologics

1.	LDL Receptors (LDL Receptor)
2.	LDL Lipoproteins (beta Lipoproteins)
3.	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
4.	Coenzyme A (CoA)
5.	Squalene Monooxygenase (Squalene Epoxidase)
6.	Squalene