abieslactone

has anti-tumor promoting activity; from several Abies genus; structure given in first source; RN & chemical name fro CA Abstract Guide 1990

Also Known As:

23-hydroxy-3-methoxylanosta-7,24-dien-26-oic acid lactone

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2014 - "In the present study, cell viability assay demonstrated that abieslactone had selective cytotoxicity against human hepatoma cell lines. " 01/01/2014 - "Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species."
2.	Neoplasms (Cancer) 09/01/1990 - "Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus." 09/01/1990 - "Abiesenonic acid methyl ester (AVB-I acid methyl ester), a triterpenoid compound prepared from abieslactone, suppressed tumor promoter-induced phenomena in vitro and in vivo; i.e., AVB-I acid methyl ester inhibited 12-o-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells and the promoting action of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene."

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Triterpenes
3.	Phospholipids (Phosphatides)
4.	Esters
5.	Carcinogens
6.	Acids
7.	anthracene