orientin

structure given in first source; RN given refers to the (D-glucopyranosyl)-isomer

Also Known As:

8-C-beta-glucopyranosyl-3',4',5,7-tetrahydroxyflav-2-en-3-one; luteolin 8-C-beta-D-glucopyranoside; luteolin-8-c-glucoside; orientine; 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy

Networked: 56 relevant articles (13 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thangaraj, Kalaiyarasu: 4 articles (01/2019 - 12/2017)
2.	Xiao, Qingfei: 3 articles (05/2022 - 01/2017)
3.	Natesan, Karthi: 3 articles (01/2019 - 01/2018)
4.	Vaiyapuri, Manju: 3 articles (10/2018 - 12/2017)
5.	An, Fang: 3 articles (10/2017 - 10/2015)
6.	Wang, Shuhua: 3 articles (10/2017 - 10/2015)
7.	Bae, Jong-Sup: 3 articles (12/2014 - 07/2014)
8.	Ku, Sae-Kwang: 3 articles (12/2014 - 07/2014)
9.	Uma Devi, P: 3 articles (09/2004 - 10/2000)
10.	Zhao, Ying: 2 articles (05/2022 - 01/2017)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2020 - "The objective of this study was to rule out the effectiveness of orientin in mast cell-mediated allergic inflammation. " 08/01/2020 - "Inhibitory effects of orientin in mast cell-mediated allergic inflammation." 11/01/2023 - "Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway." 07/01/2014 - "Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo." 12/01/2014 - "In this study, we assessed whether orientin can suppress vascular inflammation induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. "
2.	Neoplasms (Cancer) 11/15/2018 - "Therefore, orientin prevents tumor invasion and could be applied as a possible therapeutic agent for the treatment of cancer metastasis." 01/01/2016 - "Therefore, we concluded that the selected orientin analogue fenofibryl glucuronide was non-cytotoxic/non-anti-carcinogenic up to 100 μg/ml (202.389 μM) concentrations for a long term exposure i.e., till 96 hrs in human cancer cells of HepG2. " 10/01/2023 - "Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro. " 12/14/2019 - "BACKGROUND Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM), which suppresses the growth of cancer cells in vitro. " 01/01/2018 - "The present study aims to investigate the anti-cancer efficacy of orientin on 1,2 dimethyl hydrazine induced colonic aberrant crypt foci (ACF) and cell proliferation in Wistar rats. "
3.	Brain Injuries (Brain Injury) 01/01/2018 - "However, the effects of orientin on neonatal ischemic brain injury and the underlying mechanisms involved have not been studied. " 03/01/2020 - "orientin against cerebral ischemia/reperfusion induced brain injury." 01/01/2018 - "In the present study, we explored the effects of orientin on oxygen-glucose deprivation/reperfusion (OGD/RP)-induced cell injury in primary culture of rat cortical neurons using an in vitro model of neonatal ischemic brain injury. " 01/01/2021 - "Studies with various medicinal plants such as Acanthopanax senticosus, Bacopa monnieri, carnosol, Cassia mimosoides, Centella asiatica, Crocus sativus, Cuminum cyminum, curcumin, Feronia limonia, Gardenia jasminoides, Ginkgo biloba, Kaempferia parviflora, Mentha longifolia, Nigella sativa, olive, orientin, pomegranate, quercetin, rice bran, Rosa damascena, Thymus vulgaris, Viola odorata, Withania coagulans, Zingiber officinale, and Ziziphus spina-christi show a significant improvement in brain injury. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "The present study anticipates exploring the antitumor activity of orientin against colorectal carcinoma cells (HT29). " 01/01/2019 - "In conclusion, our results proposed that orientin could be a potent chemotherapeutic agent against colorectal cancer after ascertaining their molecular mechanisms." 01/01/2019 - "Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells." 12/01/2017 - "The present study intends to investigate the anti-proliferative and anti-inflammatory efficacy of Orientin in 1,2-dimethyl hydrazine (DMH) induced colorectal cancer (CRC) in rats. "
5.	Hypoxia (Hypoxemia) 01/01/2017 - "Furthermore, orientin treatment attenuated the hypoxia-induced neonatal rat cardiomyocyte apoptosis and increased cell viability. " 04/05/2016 - "Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy." 04/01/2006 - "Vehicle or orientin (3, 10, 30 micromol l(-1) was added 10 min before hypoxia and reoxygenated. " 08/01/2007 - "To study the protective effects of orientin against myocardial ischemia and hypoxia in rats. " 08/01/2007 - "[Protective effects of orientin on myocardial ischemia and hypoxia in animal models]."

Related Drugs and Biologics

1.	Flavonoids
2.	vicenin
3.	Glucose (Dextrose)
4.	Dimenhydrinate (DMH)
5.	homoorientin (isoorientin)
6.	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)
7.	Quercetin
8.	Curcumin
9.	carnosol
10.	hydrazine (hydrazine dihydrochloride)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Therapeutics
3.	Intraperitoneal Injections
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Ligation