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9- ((2- (hydroxymethyl)cyclohexyl)methyl)guanine

suppresses herpes simplex type 1 reactivation from latency; RN given refers to (cis-(+-)-isomer

Also Known As:

L 653180; L-653,180

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        9-((2-(hydroxymethyl)cyclohexyl)methyl)guanine: 2

Related Diseases

1.	Virus Diseases (Viral Diseases) 10/01/1990 - "The results showed that ACV given in the drinking water prevents, in a dose-dependent way, the evolution of the viral infection, and that L-653,180 can reverse some of the therapeutic effects of the antiviral drug. "
2.	Infections 08/01/1990 - "L-653,180 alone or in combination with interferon was ineffective as a primary or acute viral replication inhibitor and was unable to induce latent HSV-1 infection in cell culture. "
3.	Latent Infection 10/01/1990 - "Among the parameters used to evaluate the effect of the TK inhibitor mortality was increased compared to ACV treatment alone, only in the presence of low doses of ACV, whereas the establishment of latent infections in sensory ganglia was significantly increased compared to ACV treatment alone, even when high doses of ACV were administered together with L-653,180."

Related Drugs and Biologics

1.	Drinking Water
2.	Therapeutic Uses
3.	Interferons
4.	Antiviral Agents (Antivirals)