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1-O-palmitylglucuronic acid
used to modify liposomes
Also Known As:
1-O-palmityl-D-glucuronic acid; PGlcUA; palmitoyl glucuronide
Networked:
9
relevant articles (
2
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Hydroxy Acids: 94
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
1-O-palmitylglucuronic acid: 9
Acyclic Acids
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
1-O-palmitylglucuronic acid: 9
Aldehydic Acids
Uronic Acids: 152
Glucuronates: 3
1-O-palmitylglucuronic acid: 9
Carbohydrates: 22023
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
1-O-palmitylglucuronic acid: 9
Related Diseases
1.
Neoplasms (Cancer)
10/01/1994 - "
The RES-avoiding liposomal formulation using PGlcUA was effective in reducing tumors, and prolonging survival time compared with free DPPF and also DPPF in conventional liposomes.
"
04/05/1999 - "
Tumor accumulation of liposomes was obvious for PGlcUA-liposomes and PEG-liposomes from immediately after injection, but not for GM1-liposomes.
"
02/21/1996 - "
Single-dose administration of VCR (3.0 mg/kg) in PGlcUA-liposomes significantly suppressed tumor growth, and prolonged the survival time (T/C = 1.37).
"
05/01/1993 - "
Corresponding to these results, tumor was strongly imaged by a gamma-camera when 99mTc-DTPA-encapsulated PGlcUA-liposomes were used.
"
08/23/1995 - "
[2-18F]FDG-labeled liposomes sized by extrusion through a filter with various-sized pores were administered to mice bearing Meth A sarcoma, and a PET scan was performed for 120 min. Small-sized, long-circulating liposomes (100 nm in diameter) constructed with PGlcUA tended to accumulate in the tumor tissues.
"
2.
Sarcoma (Soft Tissue Sarcoma)
08/23/1995 - "
[2-18F]FDG-labeled liposomes sized by extrusion through a filter with various-sized pores were administered to mice bearing Meth A sarcoma, and a PET scan was performed for 120 min. Small-sized, long-circulating liposomes (100 nm in diameter) constructed with PGlcUA tended to accumulate in the tumor tissues.
"
07/01/1998 - "
Long-circulating liposomes composed of DPP-CNDAC, dipalmitoylphosphatidylcholine, cholesterol and palmityl-D-glucuronide (PGlcUA) (2:2:2:1 as a molar ratio), as well as liposomes containing dipalmitoylphosphatidylglycerol (DPPG) instead of palmityl-D-glucuronide and those composed of only DPP-CNDAC, were injected intravenously into Meth A sarcoma-bearing mice.
"
07/01/1996 - "
Liposomes composed of dipalmitoylphosphatidylcholine, cholesterol, and modifier, namely, GM1, distearoylphosphatidylethanolamine (DSPE)-PEG or palmityl-D-glucuronide (PGlcUA), were labelled with [2-18F]-2-fluoro-2-deoxy-D-glucose ([2-18F]FDG), and administered to mice bearing Meth A sarcoma after having been sized to 100 nm. A PET scan was started immediately after injection of liposomes and continued for 120 min. PET images and time-activity curves indicated that PEG liposomes and PGlcUA liposomes were efficiently accumulated in tumour tissues time dependently from immediately after injection.
"
Related Drugs and Biologics
1.
Liposomes (Liposome)
2.
Vincristine (Oncovin)
3.
Antineoplastic Agents (Antineoplastics)
4.
Doxorubicin (Adriamycin)
5.
1,2-Dipalmitoylphosphatidylcholine (Dipalmitoylphosphatidylcholine)
6.
Cholesterol
7.
Pentetic Acid (DTPA)
8.
Acids
9.
Glucuronides
10.
Uronic Acids
Related Therapies and Procedures
1.
Gamma Cameras (Gamma Camera)
2.
Photochemotherapy (Photodynamic Therapy)