|1.||Nojima, Y: 1 article (03/2001)|
|2.||Hayashi, J: 1 article (03/2001)|
|3.||Hiromura, K: 1 article (03/2001)|
|4.||Koizumi, R: 1 article (03/2001)|
|5.||Naruse, T: 1 article (03/2001)|
|6.||Shimizu, Y: 1 article (03/2001)|
|7.||Maezawa, A: 1 article (03/2001)|
|1.||Disseminated Intravascular Coagulation
12/01/1991 - "Effect of a selective PAF antagonist SM-10661 ((+/-)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one HCl) on experimental disseminated intravascular coagulation (DIC)."
06/01/1996 - "A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats."
01/01/1996 - "Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats."
06/01/1996 - "To elucidate the possible therapeutic efficacy of SM-12502, a novel platelet activating factor antagonist, on acute lung injury and disseminated intravascular coagulation in sepsis, we investigated the effect of SM-12502 on an endotoxin (ET)-induced septic model in rats. "
|2.||Acute Lung Injury
|4.||Hypotension (Low Blood Pressure)
03/01/1994 - "In addition, SM-12502 inhibited PAF (10 ng/kg)-induced hypotension in rats with ID50 values of 2.0 mg/kg (i.v.) or 6.5 mg/kg (p.o.). "
11/01/1994 - "Pre-treatment or post-treatment with a specific platelet activating factor (PAF) antagonist, SM-12502 ((+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one HCl, CAS 119383-00-5) inhibited the second phase of endotoxin (1 mg/kg)-induced hypotension. "
09/01/1990 - "Bronchial hyperreactivity to bombesin after the infusion of alkyl-PAF was also inhibited dose-dependently by the infusion of SM-10661, with an ID50 of 25 mg/kg. In addition, SM-10661 inhibited alkyl-PAF (0.01 micrograms/kg)-induced hypotension in rats, with an ID50 of 0.36 mg/kg intravenously or 33 mg/kg orally. "
|5.||Vascular System Injuries
|1.||Platelet Activating Factor