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dipfluzine

structure given in first source

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - Cinnarizine: 232
      - dipfluzine: 9

Experts

1.	Wang, Yongli: 4 articles (10/2020 - 08/2002)
2.	Guo, Wei: 2 articles (10/2020 - 01/2012)
3.	Wang, Yong-li: 2 articles (12/2005 - 02/2005)
4.	He, Chaoxing: 1 article (10/2020)
5.	Li, Shiji: 1 article (10/2020)
6.	Wang, Huan: 1 article (10/2020)
7.	Wang, Tianshi: 1 article (10/2020)
8.	Wang, Xiaohui: 1 article (10/2020)
9.	Du, Yingfeng: 1 article (01/2012)
10.	Kong, Dezhi: 1 article (01/2012)

Related Diseases

1.	Vascular Diseases (Vascular Disease) 10/01/2020 - "Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases and has 5 metabolites (M1∼M5) in rat urine and liver microsomes, but their biological activity is still unknown. " 01/01/2012 - "Dipfluzine hydrochloride (Dip), a novel diphenylpiperazine calcium channel blocker, has revealed the characteristics of a promising candidate for the treatment of cerebral vascular diseases in preclinical studies. "
2.	Ischemia 02/01/2005 - "Mechanism of anti-apoptotic action of dipfluzine on neuronal damage of the rat hippocampal CA1 region subjected to transient forebrain ischemia." 02/01/2005 - "To explore the relations between anti-apoptotic role of dipfluzine (DIP) and the death signaling transduction pathway initiated by CD95 molecules, and the transcription factor involved in the transcription regulation of CD95 molecules in the hippocampal CA1 region after transient forebrain ischemia. " 12/01/2005 - "Dipfluzine (0.25, 0.5 and 1 mg x kg(-1)), flunarizine 0.5 mg x kg(-1) and solvent were injected separately into lingual vein at 30 min after ischemia. " 12/01/2005 - "Dipfluzine could relieve pathological damages in the brain tissue after ischemia-reperfusion, and reduce the expressions of E-selectin, P-selectin and ICAM-1 and activities of MPO in dose-dependent manner. "
3.	Brain Ischemia (Cerebral Ischemia) 12/01/2005 - "To evaluate the effects of dipfluzine on the expressions of E-selectin, P-selectin, and ICAM-1 and the infiltration of polymorphonuclear leukocytes in brain ischemia-reperfusion rats. " 12/01/2005 - "[Effects of dipfluzine on expressions of E-selectin, P-selectin, and ICAM-1 in brain ischemia-reperfusion rats]." 01/01/1996 - "To evaluate the effects of dipfluzine ¿1-diphenyl-methyl-4-[3-(4-fluorobenzoyl)]-piperazine, Dip¿ on the intra- and extra-cellular contents of the amino acids in brain and the cortical somatosensory evoked potentials (SEP) in rats with cerebral ischemia. "
4.	Brain Edema (Cerebral Edema) 08/25/2002 - "[Effect of dipfluzine on acute ischemic brain edema in gerbils]." 05/01/1994 - "Protective effect of dipfluzine on experimental brain edema in rats." 08/25/2002 - "To examine the effect of dipfluzine (Dip), a novel calcium channel blocker first developed in China, on acute ischemic brain edema. " 05/01/1994 - "The effects of dipfluzine (1-diphenylmethyl-4-(3-(4-fluorobenzoyl))-piperazine, Dip), a new calcium antagonist developed in China, on experimental brain edema in female Wistar rats with bilateral carotid artery ligation were compared with those of cinnarizine (Cin). "
5.	Reperfusion Injury 12/01/2005 - "Dipfluzine depresses the expressions of P-selectin, E-selectin, and ICAM-1, which are correlated with their effects on the activities of MPO, suggesting that dipfluzine has anti-inflammation effect in certain extent and could protect brain tissue from ischemia-reperfusion injury."

Related Drugs and Biologics

1.	Calcium Channel Blockers (Blockers, Calcium Channel)
2.	E-Selectin
3.	P-Selectin
4.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
5.	Transcription Factors (Transcription Factor)
6.	Solvents
7.	Flunarizine
8.	Cinnarizine (Cinna)
9.	Calcium
10.	Amino Acids

Related Therapies and Procedures

1.	Ligation