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melacacidin

from Australian blackwood; causes contact dermatitis; structure given in first source

Also Known As:

3,3',4,4',7,8-hexahydroxyflavan

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        melacacidin: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        melacacidin: 2

Experts

1.	Coates, Robert M: 1 article (01/2009)
2.	Dimitriadis, Eugene: 1 article (01/2009)
3.	Grace, Mary H: 1 article (01/2009)
4.	Kandil, Fayez E: 1 article (01/2009)
5.	Wilsonb, George R: 1 article (01/2009)

Related Diseases

1.	Urticaria (Hives) 01/01/2005 - "The additional data needed to complete the safety assessment for these ingredients include (1) concentration of use; (2) identify the specific chemical constituents, and clarify the relationship between crude Acacias and their extracts and the Acacias and their extracts that are used as cosmetic ingredients; (3) data on contaminants, particularly relating to the presence of pesticide residues, and a determination of whether Acacia melanoxylon is used in cosmetics and whether acamelin (a quinone) and melacacidin (a flavin) are present in the Acacias that are being used; (4) skin sensitization study (i.e., dose response to be determined); (5) contact urticaria study at use concentration; and (6) ultraviolet (UV) absorption spectrum; if there is significant absorbance in the UVA or UVB range, then a photosensitization study may be needed. "
2.	Photosensitivity Disorders (Photodermatitis) 01/01/2005 - "The additional data needed to complete the safety assessment for these ingredients include (1) concentration of use; (2) identify the specific chemical constituents, and clarify the relationship between crude Acacias and their extracts and the Acacias and their extracts that are used as cosmetic ingredients; (3) data on contaminants, particularly relating to the presence of pesticide residues, and a determination of whether Acacia melanoxylon is used in cosmetics and whether acamelin (a quinone) and melacacidin (a flavin) are present in the Acacias that are being used; (4) skin sensitization study (i.e., dose response to be determined); (5) contact urticaria study at use concentration; and (6) ultraviolet (UV) absorption spectrum; if there is significant absorbance in the UVA or UVB range, then a photosensitization study may be needed. "
3.	Lymphoma (Lymphomas) 01/01/2009 - "acuminata heartwoods against an L1210 (mouse lymphoma) cell line led to the isolation of two flavan-3,4-diols, melacacidin (1) and isomelacacidin (2), and three flavonoids, 3,7,8,3',4'-pentahydroxyflavone (3), 7,8,3',4'-tetrahydroxyflavanone (4) and 3,7,8,3',4'-pentahydroxyflavanone (5). "

Related Drugs and Biologics

1.	Pesticide Residues (Pesticide Residue)
2.	Cosmetics
3.	acamelin
4.	4,6-dinitro-o-cresol (DNOC)
5.	quinone (benzoquinone)
6.	Flavonoids