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SDZ 33-243

cpd is non-immunosuppressive

Also Known As:

B3-243; O-acetyl C(9) cyclosporin A; OACsA; SDZ-33-243; cyclosporine A acetate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Cyclosporins: 35
      - SDZ 33-243: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Cyclosporins: 35
      - SDZ 33-243: 3

Related Diseases

1.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 09/01/1992 - "The cytotoxic activity of cyclosporin A (CsA) and the three non-immuno-suppressive CsA analogues B3-243, WO-039 and B3-665 were studied in tumor cell lines representing both classical and atypical forms of multidrug resistance (MDR): T-ALL GM3639 L100 cells selected for vincristine (vcr) resistance and displaying characteristics of classical MDR, including P-glycoprotein (pgp) expression and increased drug efflux which can be inhibited by pgp blockers (e.g. "
2.	Lung Neoplasms (Lung Cancer) 09/01/1988 - "The non-immunosuppressive analogue, B3-243, is at least as effective as CsA as an antiproliferative in human lung cancer cell lines. "
3.	Hypersensitivity (Allergy) 09/01/1992 - "Compared to LO cells, L100 cells showed a marked hypersensitivity to CsA > B3-243 > WO-039 with B3-665 being inactive. "
4.	Bone Resorption 03/01/1991 - "The effects of cyclosporine A (CsA) and one of its immunologically inactive structural analogues, cyclosporine A acetate (CsA-A) on lipopolysaccharide (LPS)-, interleukin-1 (IL-1)-, 1,25 dihydroxyvitamin D3 (1,25 D3)- and parathyroid hormone (PTH)-stimulated bone resorption were tested in mouse calvaria cultures. "

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Vincristine (Oncovin)
4.	Parathyroid Hormone (Parathormone)
5.	Lipopolysaccharides
6.	Interleukin-1 (Interleukin 1)
7.	Calcitriol (Calcijex)