Zinc Finger Protein Gli3

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

Also Known As:

GLI-Kruppel Family Member 3 Protein; Glioma-Associated Oncogene Family Zinc Finger 3 Protein; GLI Kruppel Family Member 3 Protein; Glioma Associated Oncogene Family Zinc Finger 3 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Kruppel-Like Transcription Factors: 252
      - Zinc Finger Protein Gli3
    - Repressor Proteins: 30
      - Zinc Finger Protein Gli3
  - DNA-Binding Proteins: 2009
    - Kruppel-Like Transcription Factors: 252
      - Zinc Finger Protein Gli3
    - Repressor Proteins: 30
      - Zinc Finger Protein Gli3

human GLI3 protein

Bio-Agent Context: Research Results