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SQ 28603

a selective neutral endopeptidase inhibitor

Also Known As:

SQ 28,603; SQ-28603; beta-Alanine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - SQ 28603: 5

Related Diseases

1.	Heart Failure 11/01/1995 - "lowered MAP from 151 +/- 4 to 123 +/- 5 mm Hg. Cardiomyopathic hamsters with heart failure were administered vehicle or one of the following (30 mumol/kg i.v.): the ACE inhibitor enalaprilat; the NEP inhibitor SQ-28603; or BMS. " 06/01/1993 - "The effects of a selective neutral endopeptidase inhibitor, SQ 28,603 (N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-beta-alanine), were determined in an experimental model of heart failure. " 01/01/1995 - "3. SQ 28603 stimulated urinary excretion of cyclic GMP and sodium in a dose-related manner in conscious dogs with tachycardia-induced heart failure. "
2.	Tachycardia (Tachyarrhythmias) 01/01/1995 - "3. SQ 28603 stimulated urinary excretion of cyclic GMP and sodium in a dose-related manner in conscious dogs with tachycardia-induced heart failure. "
3.	Myocardial Infarction 09/01/1991 - "We compared the cardiovascular and renal actions of the neutral endopeptidase (NEP) inhibitor, SQ 28,603, in normal rats and in rats with healed myocardial infarcts. "
4.	Bradycardia 05/01/1992 - "3. SQ 28,603 caused significant attenuation of the pressor effects of proendothelin-1 [1-38] but the associated bradycardia was unchanged. "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Enalaprilat (Vasotec)
3.	beta-Alanine
4.	Sodium
5.	Cyclic GMP
6.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
7.	proendothelin 1