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SQ 28603
a selective neutral endopeptidase inhibitor
Also Known As:
SQ 28,603; SQ-28603; beta-Alanine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Alanine: 4133
SQ 28603: 5
Related Diseases
1.
Heart Failure
11/01/1995 - "
lowered MAP from 151 +/- 4 to 123 +/- 5 mm Hg. Cardiomyopathic hamsters with heart failure were administered vehicle or one of the following (30 mumol/kg i.v.): the ACE inhibitor enalaprilat; the NEP inhibitor SQ-28603; or BMS.
"
06/01/1993 - "
The effects of a selective neutral endopeptidase inhibitor, SQ 28,603 (N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-beta-alanine), were determined in an experimental model of heart failure.
"
01/01/1995 - "
3. SQ 28603 stimulated urinary excretion of cyclic GMP and sodium in a dose-related manner in conscious dogs with tachycardia-induced heart failure.
"
2.
Tachycardia (Tachyarrhythmias)
01/01/1995 - "
3. SQ 28603 stimulated urinary excretion of cyclic GMP and sodium in a dose-related manner in conscious dogs with tachycardia-induced heart failure.
"
3.
Myocardial Infarction
09/01/1991 - "
We compared the cardiovascular and renal actions of the neutral endopeptidase (NEP) inhibitor, SQ 28,603, in normal rats and in rats with healed myocardial infarcts.
"
4.
Bradycardia
05/01/1992 - "
3. SQ 28,603 caused significant attenuation of the pressor effects of proendothelin-1 [1-38] but the associated bradycardia was unchanged.
"
Related Drugs and Biologics
1.
Neprilysin (Neutral Endopeptidase)
2.
Enalaprilat (Vasotec)
3.
beta-Alanine
4.
Sodium
5.
Cyclic GMP
6.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
7.
proendothelin 1