SDZ EAA 494 (cppene)

N-methyl-D-aspartate receptor antagonist

Also Known As:

cppene; 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid; 4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid; D-CPP-ene; SDZ EAA 494, (E)-isomer; SDZ EAA 494, (R-(E))-isomer; SDZ EAA 494, (S-(E))-isomer

Networked: 42 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - SDZ EAA 494: 42

Experts

1.	Foreman, Mark M: 1 article (08/2009)
2.	Hanania, Taleen: 1 article (08/2009)
3.	Malekiani, Sam A: 1 article (08/2009)
4.	Olivier, Berend: 1 article (08/2009)
5.	Paterson, Neil E: 1 article (08/2009)
6.	Assi, A A: 1 article (01/2001)
7.	Bespalov, A Y: 1 article (10/2000)
8.	Blokhina, E A: 1 article (10/2000)
9.	Sukhotina, I A: 1 article (10/2000)
10.	Davis, M: 1 article (01/2000)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 11/23/1992 - "Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat." 07/01/1991 - "Evaluation of a competitive NMDA antagonist (D-CPPene) in feline focal cerebral ischemia." 11/01/1990 - "We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia. " 09/01/1990 - "Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene." 09/01/1990 - "The competitive NMDA receptor antagonist D-CPP-ene is as effective as noncompetitive NMDA antagonists in reducing the amount of ischemic brain damage in this model of focal cerebral ischemia in a gyrencephalic species."
2.	Seizures (Absence Seizure) 12/19/1996 - "Audiogenic seizures were delivered 30 min after CPPene administration. " 10/01/1993 - "We report the results of the first therapeutic trial of the competitive NMDA antagonist, D-CPP-ene (SDZ EAA-494), in eight patients with intractable complex partial seizures. " 12/19/1996 - "Repeated treatment with CCPA significantly reduced the anticonvulsant properties of CPPene against audiogenic seizures. " 03/28/1996 - "D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice. " 01/01/1994 - "The anticonvulsant potency of D-CPPene, as assessed against sound-induced seizures in DBA/2 mice, was an order of magnitude higher than that of L-CPPene [ED50 clonic phase (intraperitoneal, 45 min): 1.64 mumol/kg and 16.8 mumol/kg, respectively]. "
3.	Acute Subdural Hematoma 06/01/1991 - "These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma." 06/01/1991 - "The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. " 01/01/1992 - "We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
4.	Intracranial Hemorrhages (Intracranial Hemorrhage) 06/01/1991 - "These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma."
5.	Stroke (Strokes) 01/01/2000 - "Focal cerebral ischaemia was induced by thermocoagulation of the left middle cerebral artery in aged (30 month) male Wistar rats who were pre-treated with saline or the competitive N-methyl-D-Aspartate antagonist D-CPP-ene, which has been shown to be neuroprotective in young animal models of stroke. " 03/01/1995 - "Both noncompetitive (aptiganel hydrochloride, dextrorphan) and competitive (selfotel, d-CPPene) antagonists have undergone tolerability studies in acute stroke and traumatic brain injury. "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Excitatory Amino Acid Antagonists
4.	Dizocilpine Maleate (Dizocilpine)
5.	Aminophylline (Carine)
6.	Ciprofloxacin (Cipro)
7.	Cinoxacin (Cinobac)
8.	SDZ EAA 494 (cppene)
9.	Anticonvulsants (Antiepileptic Drugs)
10.	Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Electrocoagulation (Electrocautery)