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penicillin K
biosynthesized from glutathione S-derivatives; RN given refers to parent cpd
Also Known As:
octanoylpenicillin; penicillin K, ammonium salt; penicillin K, sodium salt
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
beta-Lactams: 2386
Penicillins: 16651
penicillin K: 1
Sulfur Compounds: 278
beta-Lactams: 2386
Penicillins: 16651
penicillin K: 1
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
beta-Lactams: 2386
Penicillins: 16651
penicillin K: 1
Related Diseases
1.
Streptococcal Infections (Streptococcal Infection)
05/17/1946 - "
In the treatment of experimental pneumococcal infections in white mice, an impure preparation of K was one-sixth as active as G and one-eighth as active as X. In the treatment of experimental streptococcal infections in white mice, a pure preparation of K was one-eleventh as active as G, and one-thirtieth as active as X. The above data suggest that penicillin K is inactivated in the body to a greater extent and more rapidly than either F, G, or X, resulting in a far lower therapeutic activity than would be anticipated from its bactericidal action in vitro.
"
2.
Pneumococcal Infections
05/17/1946 - "
In the treatment of experimental pneumococcal infections in white mice, an impure preparation of K was one-sixth as active as G and one-eighth as active as X. In the treatment of experimental streptococcal infections in white mice, a pure preparation of K was one-eleventh as active as G, and one-thirtieth as active as X. The above data suggest that penicillin K is inactivated in the body to a greater extent and more rapidly than either F, G, or X, resulting in a far lower therapeutic activity than would be anticipated from its bactericidal action in vitro.
"