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9- amino- 8- fluoro- 1,2,3,4- tetrahydro- 2,4- methanoacridine

structure given in first source

Also Known As:

SM 10888; SM-10888; 2,4-Methanoacridin-9-amine, 8-fluoro-1,2,3,4-tetrahydro-, 2-hydroxy-1,2,3-propanetricarboxylate (3:2)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        Aminacrine: 77
        9-amino-8-fluoro-1,2,3,4-tetrahydro-2,4-methanoacridine: 2

Related Diseases

1.	Hypothermia 06/01/1990 - "When the ratio of the ED50 value for hypothermia to that for salivation was regarded as the index of the selectivity to the central nervous system (CNS), SM-10888 was shown to be about 3 times more selective to the CNS than the other four drugs in mice. " 06/01/1990 - "When given to mice p.o., SM-10888 induced central (hypothermia) and peripheral (salivation) cholinergic effects. "
2.	Alzheimer Disease (Alzheimer's Disease) 02/25/1991 - "When SM-10888, a novel AChE inhibitor and putative therapeutic drug for Alzheimer's disease, was injected intraperitoneally, ACh in the dialysate of the cortex increased in a dose-dependent manner. " 02/25/1991 - "Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease."

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Dialysis Solutions
3.	Acetylcholine (Acetylcholine Chloride)

Related Therapies and Procedures

1.	Cannula