06/01/1990 - "When the ratio of the ED50 value for hypothermia to that for salivation was regarded as the index of the selectivity to the central nervous system (CNS), SM-10888 was shown to be about 3 times more selective to the CNS than the other four drugs in mice. "
06/01/1990 - "When given to mice p.o., SM-10888 induced central (hypothermia) and peripheral (salivation) cholinergic effects. "
|2.||Alzheimer Disease (Alzheimer's Disease)
02/25/1991 - "When SM-10888, a novel AChE inhibitor and putative therapeutic drug for Alzheimer's disease, was injected intraperitoneally, ACh in the dialysate of the cortex increased in a dose-dependent manner. "
02/25/1991 - "Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease."
|1.||Acetylcholine (Acetylcholine Chloride)