desmethylsertraline

metabolite of sertraline

Also Known As:

CP 53261; CP 62508; CP-53261; CP-62508; N-demethylsertraline; N-desmethylsertraline; desmethylsertraline hydrochloride; norsertraline; 1-naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1S,4S)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - 1-Naphthylamine: 14
    - Sertraline: 1936
      - desmethylsertraline: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        1-Naphthylamine: 14
        Sertraline: 1936
        desmethylsertraline: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - 1-Naphthylamine: 14
      - Sertraline: 1936
        desmethylsertraline: 3

Experts

1.	Gil-Ad, Irit: 1 article (08/2013)
2.	Miron, Oded: 1 article (08/2013)
3.	Taler, Michal: 1 article (08/2013)
4.	Weizman, Abraham: 1 article (08/2013)
5.	Hori, Hikaru: 1 article (12/2008)
6.	Ikenouchi-Sugita, Atsuko: 1 article (12/2008)
7.	Nakamura, Jun: 1 article (12/2008)
8.	Ueda, Nobuhisa: 1 article (12/2008)
9.	Umene-Nakano, Wakako: 1 article (12/2008)
10.	Yoshimura, Reiji: 1 article (12/2008)

Related Diseases

1.	Myocardial Infarction 06/01/2005 - "In a platelet/endothelial biomarker substudy of the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART), the authors sought to determine whether plasma levels of sertraline and its primary metabolite N-desmethylsertraline affect the release of platelet/endothelial biomarkers. "
2.	Treatment-Resistant Depressive Disorder 12/01/2008 - "Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline."
3.	Acute Coronary Syndrome 06/01/2005 - "This is the first documented evidence that plasma release of platelet/endothelial biomarkers is directly related to the levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. " 06/01/2005 - "Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression."
4.	Neuroblastoma 08/29/2013 - "Using human neuroblastoma cells (SHSY5Y), we found that sertraline and its derivative, desmethylsertraline, at low concentrations (1-10 μM), induced potent neurotrophic activity. "

Related Drugs and Biologics

1.	Sertraline (Zoloft)
2.	Biomarkers (Surrogate Marker)
3.	Antidepressive Agents (Antidepressants)
4.	Risperidone (Risperdal Consta)