keratinocyte growth factor receptor

Balb-Mk keratinocytes possess high affinity for the KGF receptors; is an alternative splice variant of the fibroblast growth factor receptor 2 gene product and is present only on epithelial cells

Also Known As:

Networked: 68 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ishiwata, Toshiyuki: 7 articles (04/2012 - 05/2004)
2.	Naito, Zenya: 7 articles (04/2012 - 05/2004)
3.	Brackett, Daniel J: 5 articles (01/2015 - 11/2003)
4.	Pento, J Thomas: 5 articles (01/2015 - 11/2003)
5.	Zang, Xiao-Ping: 4 articles (12/2010 - 11/2003)
6.	Brueggemeier, Robert W: 3 articles (01/2015 - 11/2007)
7.	Lerner, Megan R: 3 articles (01/2015 - 11/2003)
8.	Nakazawa, Nando: 3 articles (02/2009 - 06/2007)
9.	Kudo, Mitsuhiro: 3 articles (12/2007 - 05/2004)
10.	Akiyama, Naotaro: 2 articles (10/2015 - 11/2014)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2015 - "Also, we demonstrate that KGF-ELP selectively enhances macropinocytosis in cancer cells expressing high levels of the keratinocyte growth factor receptor (KGFR). " 01/01/2015 - "Keratinocyte growth factor receptor: a therapeutic target in solid cancer." 02/01/2009 - "KGF is not commonly produced by human cancer cells, but the KGF receptor (KGFR) is expressed in most cancer cells and particularly highly expressed in well-differentiated types of cancer. " 11/01/2006 - "KGF/KGFR (KGF receptor) signaling has also been demonstrated in the progression of many types of human cancer. " 11/01/2006 - "A Comparison of KGF Receptor Expression in Various Types of Human Cancer."
2.	Carcinoma (Carcinomatosis) 01/23/1997 - "Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas." 09/01/2002 - "The objective of this study was to assess the effect of repifermin on in vitro tumor cell proliferation and in vivo tumor growth using a variety of human carcinoma cell lines with differing growth rates and levels of KGF receptor (KGFR) expression. " 04/01/2012 - "Keratinocyte growth factor (KGF), also known as fibroblast growth factor-7, and KGF receptor (KGFR) play important roles in the growth of epithelial cells and are overexpressed in a variety of malignant epithelial tumors, including pancreatic ductal adenocarcinoma (PDAC). " 07/01/2008 - "This study was undertaken to investigate the radiosensitizing effects of fibroblast growth factor receptor 2IIIb (FGFR2IIIb) in androgen-independent human prostate carcinoma PC-3 cells devoid of normally resident epithelial cell FGFR2IIIb. "
3.	Cholesteatoma 04/01/2008 - "Keratinocyte growth factor receptor (KGF-R) in cholesteatoma tissue." 09/01/1997 - "All surgical specimens of cholesteatoma and most normal ear skin samples expressed detectable levels of KGF and KGF receptor (KGFR). " 09/01/2010 - "A previous study has reported that the expression of KGF receptor is increased in more differentiated areas of the cholesteatoma tissue, whereas the expression of the epidermal growth factor receptor is associated with proliferative and migratory areas of the lesion. "
4.	Prostatic Neoplasms (Prostate Cancer) 07/01/2014 - "Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells." 08/01/1995 - "In situ hybridization studies with digoxigenin-labeled oligonucleotides (anti-sense and sense controls) were employed to examine KGF and KGF receptor mRNA expression in prostate cancer. "
5.	Gingival Hyperplasia 10/01/2002 - "The present study was therefore carried out to determine whether expression of the keratinocyte growth factor receptor is up-regulated in gingival hyperplasia compared with normal gingiva. " 10/01/2002 - "These findings suggest that the keratinocyte growth factor-receptor pathway of mesenchymal-epithelial interaction could play an important part in the molecular pathogenesis of gingival hyperplasia." 10/01/2002 - "Keratinocyte growth factor receptor is up-regulated in cyclosporin A-induced gingival hyperplasia."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	ErbB Receptors (EGF Receptor)
3.	Fibroblast Growth Factor 10
4.	Fibroblast Growth Factor 7
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
6.	Epidermal Growth Factor (EGF)
7.	Transforming Growth Factor beta3 (TGF beta 3)
8.	Transforming Growth Factor beta1 (TGF beta 1)
9.	DNA Primers
10.	Antisense Oligonucleotides

Related Therapies and Procedures

1.	Conservative Treatment