|1.||Friedman, Henry S: 10 articles (10/2009 - 05/2002)|
|2.||Dolan, M Eileen: 10 articles (11/2008 - 05/2002)|
|3.||Pegg, Anthony E: 9 articles (05/2011 - 05/2002)|
|4.||McLendon, Roger E: 8 articles (02/2012 - 05/2002)|
|5.||Bigner, Darell D: 7 articles (10/2009 - 05/2002)|
|6.||Gururangan, Sridharan: 7 articles (10/2009 - 05/2002)|
|7.||Moschel, Robert C: 7 articles (01/2006 - 05/2002)|
|8.||Gerson, Stanton L: 6 articles (05/2012 - 05/2002)|
|9.||Quinn, Jennifer A: 6 articles (10/2009 - 05/2002)|
|10.||Sampson, John H: 6 articles (10/2009 - 05/2002)|
07/01/1990 - "O6-Benzylguanine was highly effective in depleting the alkyltransferase activity of cultured human colon tumor (HT29) cells. "
03/01/2007 - "A few recent studies have described analogs of O6-benzylguanine targeting defined pathways of cancer cells that can be used to improve the selectivity of O6-benzylguanine-based inhibitors for cancer cells. "
03/01/2003 - "Depletion of MGMT by O6-benzylguanine (BG) sensitizes tumor cells to TMZ, and this combination is currently used in clinical trials. "
05/01/2002 - "An inhibitor to AGT, O(6)-benzylguanine (BG), depletes AGT in human tumors without associated toxicity and is now in phase II clinical trials. "
05/01/2001 - "These results demonstrate that p53 is a negative regulator of MGMT gene expression and can create a MGMT-depleted state in human tumors similar to that achieved by O(6)-benzylguanine, a potent inhibitor of MGMT currently undergoing clinical trials. "
11/01/1998 - "Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma."
07/21/2014 - "Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry."
01/01/2004 - "O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas."
03/01/1992 - "We have previously shown that O6-benzylguanine can be used to deplete cells of the DNA repair protein O6-alkylguanine-DNA alkyltransferase and to enhance the sensitivity of human glioma (SF767) and colon tumor (HT29) cells to the cytotoxic effects of alkylnitrosoureas. "
01/01/1990 - "Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea."
|3.||Melanoma (Melanoma, Malignant)
10/01/2006 - "Aim of the present study was to investigate the molecular mechanisms underlying acquired resistance of melanoma cells to TMZ and the effect of O6-benzylguanine (BG), a specific MGMT inhibitor, on the development of a TMZ-resistant phenotype. "
07/01/1991 - "For example, HT29 cells (alkyltransferase activity, 381 fmol/mg protein) exhibited a greater degree of enhancement when treated with O6-benzylguanine than SF767 (77 fmol/mg protein) and M19-MEL melanoma (36 fmol/mg protein) cells. "
03/01/2006 - "This study investigated whether the therapeutic index of regional melanoma therapy using parenteral temozolomide could be improved by chemomodulation with O6-benzylguanine (O6BG), an inhibitor of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT). "
01/27/2009 - "MGMT inactivation by O(6)-benzylguanine sensitized all melanoma cell lines expressing MGMT to TMZ and fotemustine-induced apoptosis, and MGMT transfection attenuated the apoptotic response. "
11/01/2003 - "We carried out complementary strategies that consisted of MGMT cDNA transfection in CAL77 Mer- melanoma cells and of MGMT inhibition with O6-benzylguanine (BG) in A375 Mer+ melanoma cells. "
|4.||Glioblastoma (Glioblastoma Multiforme)
12/01/2003 - "In this study the authors investigated the ability of O6-benzylguanine (BG), an AGT inhibitor, to sensitize a glioblastoma cell line resistant to TMZ. "
02/01/2009 - "Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme."
08/01/2006 - "In MGMT-positive glioblastomas, depletion of MGMT by the addition of O(6)-benzylguanine significantly enhances the antitumor effect of concurrent radiation + temozolomide. "
10/01/2013 - "MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NFκB and mutant p53."
03/01/2007 - "Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma."
|5.||Colonic Neoplasms (Colon Cancer)
05/01/1995 - "Patients with colon cancer would appear to be prime candidates for studies utilizing O6-benzylguanine to deplete alkyltransferase prior to therapy with a nitrosourea, triazine, or tetrazine."
01/26/1993 - "Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone."
04/10/1999 - "DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts."
11/01/1997 - "O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU."
01/26/1993 - "To investigate the ability of a direct alkyltransferase inhibitor, O6-benzylguanine, to reverse the nitrosourea resistance of human colon cancer cells, we studied the VACO 6 cell line which has high alkyltransferase and is completely resistant to BCNU at maximal tolerated doses in the xenograft model. "
|3.||decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymer (Gliadel)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)