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Lys(47)- hirudin
recombinant variant of hirudin
Also Known As:
hirudin, Lys(47)-; 47-Lys-hirudin; hirudin, lysine(47)-; rHV2-Lys47
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Recombinant Proteins: 2754
Lys(47)- hirudin: 1
Serpins: 906
Antithrombin Proteins: 6
Hirudins: 707
Lys(47)- hirudin: 1
Peptides: 82426
Serpins: 906
Antithrombin Proteins: 6
Hirudins: 707
Lys(47)- hirudin: 1
Related Diseases
1.
Venous Thrombosis (Deep-Vein Thrombosis)
04/12/1990 - "
Thus recombinant hirudin rHV2-Lys47 appears as a promising potent antithrombotic agent for the prevention of thrombin-dependent venous thrombosis and disseminated intravascular coagulation.
"
2.
Thrombosis (Thrombus)
04/12/1990 - "
Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat.
"
04/12/1990 - "
In this model natural recombinant hirudins, rHV2 and rHV2-Lys47 injected 5 min before thrombo-plastin totally inhibited thrombosis in the same micrograms range as heparin or natural hirudin extracted from leeches.
"
3.
Disseminated Intravascular Coagulation
04/12/1990 - "
Variants rHV2-Lys47 (30 micrograms/kg) and rHV2-Arg47 (157 micrograms/kg) injected 5 min before thromboplastin prevented by 90 to 100% the drop in platelet count observed during the disseminated intravascular coagulation induced by thromboplastin injection.
"
04/12/1990 - "
Thus recombinant hirudin rHV2-Lys47 appears as a promising potent antithrombotic agent for the prevention of thrombin-dependent venous thrombosis and disseminated intravascular coagulation.
"
Related Drugs and Biologics
1.
Thromboplastin (Tissue Factor)
2.
Thrombin
3.
Hirudins
4.
Heparin (Liquaemin)
5.
Fibrinolytic Agents (Antithrombotic Agents)
6.
plastin