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Lys(47)- hirudin

recombinant variant of hirudin

Also Known As:

hirudin, Lys(47)-; 47-Lys-hirudin; hirudin, lysine(47)-; rHV2-Lys47

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Lys(47)- hirudin: 1
  - Serpins: 906
    - Antithrombin Proteins: 6
      - Hirudins: 707
        Lys(47)- hirudin: 1
- Peptides: 82426
  - Serpins: 906
    - Antithrombin Proteins: 6
      - Hirudins: 707
        Lys(47)- hirudin: 1

Related Diseases

1.	Venous Thrombosis (Deep-Vein Thrombosis) 04/12/1990 - "Thus recombinant hirudin rHV2-Lys47 appears as a promising potent antithrombotic agent for the prevention of thrombin-dependent venous thrombosis and disseminated intravascular coagulation."
2.	Thrombosis (Thrombus) 04/12/1990 - "Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. " 04/12/1990 - "In this model natural recombinant hirudins, rHV2 and rHV2-Lys47 injected 5 min before thrombo-plastin totally inhibited thrombosis in the same micrograms range as heparin or natural hirudin extracted from leeches. "
3.	Disseminated Intravascular Coagulation 04/12/1990 - "Variants rHV2-Lys47 (30 micrograms/kg) and rHV2-Arg47 (157 micrograms/kg) injected 5 min before thromboplastin prevented by 90 to 100% the drop in platelet count observed during the disseminated intravascular coagulation induced by thromboplastin injection. " 04/12/1990 - "Thus recombinant hirudin rHV2-Lys47 appears as a promising potent antithrombotic agent for the prevention of thrombin-dependent venous thrombosis and disseminated intravascular coagulation."

Related Drugs and Biologics

1.	Thromboplastin (Tissue Factor)
2.	Thrombin
3.	Hirudins
4.	Heparin (Liquaemin)
5.	Fibrinolytic Agents (Antithrombotic Agents)
6.	plastin