HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Ro 31-7549

structure

Also Known As:

Bis VIII; Ro-31-7549; bisindolylmaleimide VIII; 1H-Pyrrole-2,5-dione,3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Min: 1 article (12/2012)
2.	Song, Jinning: 1 article (12/2012)
3.	Sun, Leitao: 1 article (12/2012)
4.	Wang, Xiaohong: 1 article (12/2012)
5.	Zhang, Wensheng: 1 article (12/2012)
6.	Arnold, Diana: 1 article (04/2003)
7.	Brunner, Thomas: 1 article (04/2003)
8.	Corazza, Nadia: 1 article (04/2003)
9.	Herren, Simon: 1 article (04/2003)
10.	Jakob, Sabine: 1 article (04/2003)

Related Diseases

1.	Autoimmune Diseases (Autoimmune Disease) 01/01/1999 - "Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases." 01/01/1999 - "Administration of bisindolylmaleimide VIII to rats during autoantigen stimulation prevented the development of symptoms of T cell-mediated autoimmune diseases in two models, the Lewis rat model of experimental allergic encephalitis and the Lewis adjuvant arthritis model. " 04/01/2003 - "Bisindolylmaleimide VIII (Bis VIII), a PKC inhibitor, can sensitize T cells for death receptor-induced apoptosis and thus can inhibit the development of T cell-mediated autoimmune disease in vivo. "
2.	Intracranial Vasospasm 12/01/2012 - "Application of RO-31-7549 reduced the expression of ET receptors and reduced cerebral vasospasm, suggesting that inhibition of PKC signaling pathway could effectively reduce DCVS after SAH."
3.	Neoplasms (Cancer) 08/09/2002 - "These results suggest that the enhanced and persistent activation of the JNK/p38 and the decreased mitochondrial membrane potential play a crucial role in synergistic induction of the death receptor-mediated apoptosis by Bis VIII. The unique ability of Bis VIII to enhance DR5-mediated apoptosis signal transduction discloses a potential utility of this compound in combination with anti-DR5 antibody in cancer therapy."
4.	Infections 04/01/2003 - "Importantly, Bis VIII administration during an acute lymphocytic choriomeningitis virus (LCMV) infection causes the depletion of virus-specific CD8+ T cells and subsequently impaired cytotoxicity and virus clearance. " 04/01/2003 - "We conclude that resistance to death receptor-induced apoptosis is crucial for the efficient induction of a protective immune response, and that Bis VIII-based immunotherapies have to be applied under well-controlled conditions to avoid the induction of immune incompetence and the inability to respond to pathogen infection."
5.	Encephalitis (Encephalitis, Rasmussen) 01/01/1999 - "Administration of bisindolylmaleimide VIII to rats during autoantigen stimulation prevented the development of symptoms of T cell-mediated autoimmune diseases in two models, the Lewis rat model of experimental allergic encephalitis and the Lewis adjuvant arthritis model. "

Related Drugs and Biologics

1.	Death Domain Receptors
2.	Ro 31-7549
3.	Autoantigens

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy