MDL 74270

the N,N,N,-trimethylethanaminium analog of alpha-tocopherol; a hydrophilic cardioselective free radical scavenger

Also Known As:

6-acetyloxy-3,4-dihydro-N,N,N,2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethaniminium 4-methylbenzene sulfonate; MDL-74270; 2H-1-Benzopyran-2-ethanaminium, 6-(acetyloxy)-3,4-dihydro-N,N,N,2,5,7,8-heptamethyl-, salt with 4-methylbenzenesulfonic acid (1:1)

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - MDL 74270: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - MDL 74270: 1

Related Diseases

1.	Myocardial Infarction 01/17/1991 - "In the present study the effects of a cardioselective, free radical scavenger, MDL 74270, which is an analogue of alpha-tocopherol, on myocardial infarct size in an anaesthetised rat model of coronary artery ligation (60 min) and reperfusion (30 min) has been evaluated. "
2.	Infarction (Infarctions) 01/17/1991 - "Infusion of MDL 74270 (0.3-3.0 mg/kg per h) commencing 10 min before occlusion until the end of reperfusion significantly reduced infarct size. "

Related Drugs and Biologics

1.	alpha-Tocopherol
2.	Free Radical Scavengers

Related Therapies and Procedures

1.	Ligation