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aristololactam BII
isolated from Saururus cernuus; structure given in first source
Also Known As:
cepharanone B
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Aristolochic Acids: 79
aristololactam BII: 1
Nitro Compounds: 66
Aristolochic Acids: 79
aristololactam BII: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Aristolochic Acids: 79
aristololactam BII: 1
Experts
1.
Ayuso, M J
: 1 article (09/2001)
2.
Bermejo, A
: 1 article (09/2001)
3.
Cortes, D
: 1 article (09/2001)
4.
López-Lázaro, M
: 1 article (09/2001)
5.
Martín-Cordero, C
: 1 article (09/2001)
Related Diseases
1.
Neoplasms (Cancer)
09/01/2001 - "
The six compounds showed cytotoxic activity, with cepharanone B being the most cytotoxic one, even more than the antineoplastic agent etoposide on two cancer cell lines, although it is the only one that does not act as a DNA topoisomerase poison.
"
09/01/2001 - "
In the search for cytotoxic natural products as DNA topoisomerase poisons, we have assessed six annonaceus compounds (the acetogenins annonacin and rolliniastatin-1, the styryl-lactones etharversin and altholactone and the alkaloids thaligrisine and cepharanone-B) for cytotoxic activity against three human cancer cell lines and then we evaluated these compounds as DNA topoisomerase poisons.
"
Related Drugs and Biologics
1.
Acetogenins
2.
A-Form DNA (A-DNA)
3.
Poisons
4.
Lactones
5.
Etoposide (VP 16)
6.
Type I DNA Topoisomerases (Topoisomerase I)
7.
Antineoplastic Agents (Antineoplastics)
8.
Alkaloids
9.
altholactone
10.
thaligrisine