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E 6080
Also Known As:
6-hydroxy-2-(4-sulfamoylbenzylamine)-4,5,7-trimethylbenzothiazole hydrochloride; E-6080; E6080
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
E 6080: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
E 6080: 4
Related Diseases
1.
Asthma (Bronchial Asthma)
01/01/1991 - "
These results suggest that E6080 may prove to be effective for the treatment of asthma, in which large amounts of leukotrienes (LTs) are elaborated.
"
2.
Allergic Rhinitis
01/01/1993 - "
To define the role of platelet activating factor (PAF) in allergic rhinitis, we examined the effects of anti-PAF agents (WEB2086, SM10661) on the changes of nasal airway resistance (NAR) and nasal symptoms after topical antigen challenge in actively sensitized guinea pigs and compared these with the changes brought by anti-leukotriene (LT) agent (FPL 55712), 5-lipoxygenase inhibitor (E6080), anti-allergic agent (azelastine), and anti-histamine agent (mepyramine maleate).
"
3.
Leukemia
01/01/1992 - "
The potent inhibition by E6080 might be a result of the inhibition of 5-lipoxygenase, since 5-lipoxygenase in rat basophilic leukemia cell was inhibited by E6080 with an IC50 of 0.2 microM.
"
4.
Inflammation (Inflammations)
09/01/1994 - "
In the present investigation, the effects of selective inhibitors of 5-lipoxygenase (5-LO), zileuton and TZI-41127, E-6080, AA-861 and antagonists of leukotriene B4 (LTB4) receptors, SC-41930, and SC-51146 and a selective cyclooxygenase inhibitor, indomethacin, were examined in TPA-induced acute mouse dermal inflammation.
"
5.
Bronchial Spasm
01/01/1991 - "
Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs.
"
01/01/1991 - "
6-Hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080), an orally active and selective 5-lipoxygenase inhibitor, dose-dependently inhibited the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs.
"
Related Drugs and Biologics
1.
Leukotrienes
2.
Lipoxygenase Inhibitors
3.
Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4.
Antigens
5.
Anti-Allergic Agents (Antiallergic Agents)
6.
Leukotriene B4 Receptors (Leukotriene B4 Receptor)
7.
Cyclooxygenase Inhibitors
8.
Pyrilamine (Mepyramine)
9.
Platelet Activating Factor
10.
Ovalbumin