HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3-amino-1,2,4-benzotriazine-1-oxide

structure given in first source

Also Known As:

SR 4317; SR-4317; WIN 64012; WIN-64012

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - 3-amino-1,2,4-benzotriazine-1-oxide: 4

Experts

1.	Pruijn, Frederik B: 2 articles (06/2004 - 01/2004)
2.	Siim, Bronwyn G: 2 articles (06/2004 - 01/2004)
3.	Wilson, William R: 2 articles (06/2004 - 01/2004)
4.	Hicks, Kevin O: 1 article (06/2004)
5.	Brown, J Martin: 1 article (01/2004)
6.	Hay, Michael P: 1 article (01/2004)
7.	Hogg, Alison: 1 article (01/2004)
8.	Sturman, Joanna R: 1 article (01/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/15/2004 - "Coadministration of SR 4317 (1 mmol/kg) with TPZ at a subtherapeutic dose (0.133 mmol/kg) significantly enhanced hypoxic cell killing in HT29 tumor xenografts without causing oxic cell killing, and the combination at its maximum tolerated dose was less toxic to hypoxic cells in the retina than was TPZ alone at its maximum tolerated dose. " 05/01/1993 - "Tumor/plasma ratios (percentages) for SR 4233 were 32% compared to 174 (SR 4317) and 196% (SR 4330), respectively. "
2.	Carcinoma (Carcinomatosis) 06/01/2004 - "We have determined the O(2) dependence of the metabolism of TPZ to its reduction product SR 4317, and its cytotoxicity, in stirred suspensions of HT29 colon carcinoma cells while monitoring O(2) in solution with an Oxylite trade mark probe. "
3.	Hypoxia (Hypoxemia) 07/22/1992 - "Reduction of SR 4233 to the mono-N-oxide SR 4317 (3-amino-1,2,4-benzotriazine-1-oxide) is NADPH, enzyme and hypoxia dependent. "

Related Drugs and Biologics

1.	Tirapazamine (SR 4233)
2.	Suspensions
3.	Solutions
4.	Oxides
5.	NADP (NADPH)
6.	Enzymes
7.	3-amino-1,2,4-benzotriazine