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propylmethylenedioxyindene
Also Known As:
pr-MDI
Networked:
6
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
propylmethylenedioxyindene: 6
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
propylmethylenedioxyindene: 6
Related Diseases
1.
Ulcer
01/01/1990 - "
1. Propyl-methylenedioxyindene (pr-MDI) is an intracellularly acting calcium antagonist which protects against cold/restraint-induced stress ulcers in rats.
"
01/01/1990 - "
Since propyl-methylenedioxyindene (pr-MDI) exhibits significant protective effects against stress-induced ulcers in rats at subcardiovascular doses (10-30 mg/kg, i.p.), the aim of the present study was to explore the effect of this intracellular calcium antagonist on cysteamine-induced duodenal ulcers at the same low doses.
"
01/01/1990 - "
3. The antiulcer activity of pr-MDI (10-30 mg/kg) was examined in the cold (4 degree C)/restraint (3 hr) stress-induced ulcer model in male rats, and compared with the effects of the H2-blocker cimetidine (10-30 mg/kg) and the calcium channel blocker verapamil (11-32 mg/kg).
"
2.
Duodenal Ulcer (Curling's Ulcer)
01/01/1990 - "
Since propyl-methylenedioxyindene (pr-MDI) exhibits significant protective effects against stress-induced ulcers in rats at subcardiovascular doses (10-30 mg/kg, i.p.), the aim of the present study was to explore the effect of this intracellular calcium antagonist on cysteamine-induced duodenal ulcers at the same low doses.
"
3.
Stomach Ulcer (Gastric Ulcer)
01/01/1990 - "
Since central TRH is suggested as the brain mediator responsible for cold-restraint stress gastric ulcers in rats, the inhibitory action of pr-MDI was evaluated in the TRH-induced gastric lesion model.
"
4.
Seizures (Absence Seizure)
01/01/1989 - "
4. In the pentylenetetrazol-induced seizure test, the order of effectiveness of the three calcium antagonists in attenuating the severity of the clonic and tonic seizures in mice was: nifedipine greater than verapamil greater than pr-MDI.
"
5.
Contracture
06/01/1981 - "
The present investigation further substantiates this hypothesis by providing evidence that pr-MDI inhibits caffeine-induced contractures (which are mediated by intracellular calcium) of the isolated rat hemidiaphragm skeletal muscle both in the presence and in the absence of extracellular calcium.
"
Related Drugs and Biologics
1.
Calcium
2.
Cysteamine (Mercaptamine)
3.
Verapamil (Calan)
4.
Pentylenetetrazole (Metrazol)
5.
Nifedipine (Adalat)
6.
Cimetidine (Biomet)
7.
Calcium Channel Blockers (Blockers, Calcium Channel)
8.
Caffeine (No Doz)