4-phenyl-3-butenoic acid

an inhibitor of peptidyl glycine hydroxylase (peptide amidating enzyme); RN given refers to cpd without isomeric designation

Also Known As:

4-phenyl-3-butenoic acid, (E)-isomer; styrylacetic acid

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Carcinoma (Carcinomatosis) 08/01/2015 - "4-Phenyl-3-butenoic acid (PBA) is an inhibitor of peptidylglycine alpha-amidating monooxygenase with anti-inflammatory properties that has been shown to inhibit the growth of ras-mutated epithelial and human lung carcinoma cells. " 01/01/2012 - "p38 MAPK activation, JNK inhibition, neoplastic growth inhibition, and increased gap junction communication in human lung carcinoma and Ras-transformed cells by 4-phenyl-3-butenoic acid."
2.	Thyroid Neoplasms (Thyroid Cancer) 04/30/1990 - "Incubation of rat thyroid carcinoma CA77 cells in the presence of 4-phenyl-3-butenoic acid led to a decrease in the levels of intracellular amidating activity and of thyrotropin-releasing hormone, an amidated peptide produced by these cells. "
3.	Lung Neoplasms (Lung Cancer) 12/01/2004 - "4-Phenyl-3-butenoic acid (PBA) is an irreversible turnover-dependent inhibitor of PAM in vitro and has been shown to decrease lung cancer cell proliferation by inhibiting the synthesis of amidated growth factors. "
4.	Edema (Dropsy) 03/01/2007 - "We have demonstrated previously that 4-phenyl-3-butenoic acid (PBA) is a PAM inhibitor, and we have also shown that in vivo inhibition of serum PAM by PBA correlates with this compound's ability to inhibit carrageenan-induced edema in the rat. "

1.	p38 Mitogen-Activated Protein Kinases
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Peptides (Polypeptides)
4.	Carrageenan
5.	peptidylglycine monooxygenase
6.	pyroglutaminyl-seryl-leucinamide