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NGM-1
may be the Cad blood group antigen
Also Known As:
GalNAc(1--4)(NeuAc(2--3))Gal(1--4)GlcNAc(1--3)Gal(1--4)Glc(1-1)Cer
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Glycoconjugates: 1353
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M2) Ganglioside: 233
NGM-1: 3
Lipids: 114793
Glycolipids: 2799
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M2) Ganglioside: 233
NGM-1: 3
Membrane Lipids: 1591
Sphingolipids: 3208
Glycosphingolipids: 1659
Acidic Glycosphingolipids: 20
Gangliosides: 3319
G(M2) Ganglioside: 233
NGM-1: 3
Related Diseases
1.
Neoplasms (Cancer)
12/15/1991 - "
The study on differential expression of NGM-1 in gastric fundic mucosa, pyloric mucosa, gastric cancer, and various other tissues indicated that NGM-1 existed specifically in fundic mucosa.
"
12/15/1991 - "
Our conclusion is that the limited expression of NGM-1 in fundic mucosa and the increase of GM2 in cancer are attributed to two types of beta 1,4GalNAc transferases localized in each region with different substrate specificity; the one in fundic mucosa transfers GalNAc to SPG but not to GM3, and the other one enhanced in cancer transfers GalNAc to GM3 but not to SPG.
"
2.
Stomach Neoplasms (Stomach Cancer)
01/02/1993 - "
These results demonstrate that the expression of NGM-1 is induced by DMF specifically in gastric-cancer cells, and suggest the possibility that NGM-1 is a differentiation-related molecule.
"
05/15/1990 - "
These glycolipids were assigned as NGM-1, -2, and -3. They were completely lost in all carcinoma tissues and in non-cancerous gastric mucosa from two cases of gastric cancer, and they were also not detected in the ganglioside fraction of small or large intestine.
"
12/15/1991 - "
A glycolipid detected in human gastric mucosa with anti-GM2 monoclonal antibody was characterized to be GalNAc beta 1-4[NeuAc alpha 2-3]Gal beta 1-4GlcNAc beta 1-3Gal 1-4Glc-Cer (NGM-1), which was lost in gastric cancer tissue with complementary increase of GM2 sharing the same terminal carbohydrate structure as NGM-1 (Dohi, T., Ohta, S., Hanai, N., Yamaguchi, K., and Oshima, M.
"
3.
Peptic Ulcer (Peptic Ulcers)
05/15/1990 - "
Of these glycolipids, the major one, NGM-1, was isolated from the pooled ganglioside fraction of normal gastric mucosa obtained from cases of peptic ulcer.
"
4.
Carcinoma (Carcinomatosis)
05/15/1990 - "
These glycolipids were assigned as NGM-1, -2, and -3. They were completely lost in all carcinoma tissues and in non-cancerous gastric mucosa from two cases of gastric cancer, and they were also not detected in the ganglioside fraction of small or large intestine.
"
Related Drugs and Biologics
1.
Glycolipids
2.
Transferases
3.
Gangliosides
4.
Carbohydrates
5.
Monoclonal Antibodies