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N,N'- bis(2- pyridylmethylene)- 1,4- butanediamine (N,N',N'',N''')-Cu(II)diperchlorate
Also Known As:
Cu-PuPy; CuPUPY; CuPu(Py)2; copper-putrescine-pyridine
Networked:
6
relevant articles (
3
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Imines: 310
Schiff Bases: 490
N,N'-bis(2-pyridylmethylene)-1,4-butanediamine (N,N',N'',N''')-Cu(II)diperchlorate: 6
Organometallic Compounds: 64
N,N'-bis(2-pyridylmethylene)-1,4-butanediamine (N,N',N'',N''')-Cu(II)diperchlorate: 6
Related Diseases
1.
Inflammation (Inflammations)
10/01/1993 - "
The antiinflammatory efficacy of CuPu(Py)2 ([[N,N'-bis(2-pyridylmethylene)-1,4-butanediamine] (N,N',N'',N''')]-Cu2+), a serum stable active center analog of Cu2Zn2superoxide dismutase (SOD), was tested in vitro and in vivo in male Wistar rats suffering from potassium peroxochromate-induced inflammation.
"
2.
Hepatitis
10/01/1995 - "
1. The anti-inflammatory and hepatoprotective efficacy of CuPu(Py)2 ((N,N'-bis(2-pyridyl-methylene)-1,4-butanediamine) (N,N',N",N")-Cu2+), a serum-stable, copper-di-Schiffbase active centre analogue of Cu2Zn2 superoxide dismutase was tested in male NMNR mice suffering from endotoxin/galactosamine-induced hepatitis.
"
3.
Arthritis (Polyarthritis)
01/01/1994 - "
The anti-arthritic and anti-inflammatory efficacy of CuPu(Py)2 ([N,N'-bis(2-pyridylmethylene)-1,4-butanediamine] (N,N',N",N"))-Cu(II), a serum-stable active center analogue of Cu2Zn2-superoxide dismutase (SOD; EC 1.15.1.1), was tested in male DBA/1 x B10A (4R) mice suffering from potassium-peroxochromate-induced (PIA) or collagen type II-induced arthritis (CIA).
"
4.
Acute Erythroblastic Leukemia (Erythroleukemia)
10/09/1991 - "
Evidence was obtained for the occurrence of the same reaction pathway in human K562 erythroleukemia cells: CuPUPY was more toxic to cells in which glutathione synthesis was inhibited by buthionine sulfoximine.
"
05/01/1990 - "
CuPUPY, a low molecular weight copper complex with properties typical of a Cu2Zn2 SOD active center analog was shown to display pronounced toxicity upon incubation with human K562 erythroleukemia cells, while the ligand, CuSO4 or CuEDTA did not affect vitality.
"
5.
Neoplasms (Cancer)
01/01/1990 - "
When four doses of 5 mumol/kg CuPu(Py)2 and CuPu(Im)2, respectively, were administered intratumorally, reduction in tumor size, delay of metastasis and a significant increase in survival of the hosts were observed, resulting in 75% of total remissions.
"
Related Drugs and Biologics
1.
Putrescine
2.
potassium tetraperoxochromate
3.
Copper
4.
Collagen Type II (Type II Collagen)
5.
Superoxide Dismutase
6.
Galactosamine
7.
Endotoxins
8.
Buthionine Sulfoximine
9.
Ligands
10.
Glutathione (Reduced Glutathione)