Ro 09-1390

structure given in first source

Also Known As:

N(4)-trimethoxybenzoyl-5'-deoxy-5-fluorocytidine; N(4)-trimethoxybenzoyl-5-fluoro-5'-deoxycytidine; Ro-09-1390; Cytidine, 5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)-

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Deoxycytidine: 307
        Ro 09-1390: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Deoxycytidine: 307
        Ro 09-1390: 1
  - Deoxyribonucleosides: 34
    - Deoxycytidine: 307
      - Ro 09-1390: 1

Related Diseases

Neoplasms (Cancer)

04/01/1990 - "The activity of Ro 09-1390 was partly associated with cytidine deaminase in the tumors treated. "
04/01/1990 - "Ro 09-1390 appeared to be more effective against tumors with a high concentration of the enzyme by which the major metabolite 5'-deoxy-5-fluorocytidine (5'-dFCyd) is metabolized to 5'-dFUrd."
04/01/1990 - "The present study compared the antitumor activity and immunotoxicity of Ro 09-1390 with those of 5'-dFUrd, 5-fluorouracil (5-FUra) and tegafur in various transplantable tumor models. "

Related Drugs and Biologics

1.	Enzymes
2.	5'-deoxy-5-fluorocytidine
3.	Tegafur
4.	Fluorouracil (Carac)
5.	Cytidine Deaminase