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bepafant

RN given from Toxlit 6/90; PAF antagonist
Also Known As:
6-(2-chlorophenyl)-8,9-dihydro-1-methyl-8-(4-morpholinylcarbonyl)-4H,7H-cyclopenta(4,5)thieno(3,5-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine; WEB 2170; WEB-2170; WEB2170
Networked: 73 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jancar, Sonia: 3 articles (01/2010 - 01/2007)
2. Vannucchi, Alessandro M: 2 articles (10/2009 - 05/2002)
3. Cellai, Cristina: 2 articles (10/2009 - 05/2002)
4. Paoletti, Francesco: 2 articles (10/2009 - 05/2002)
5. Laurenzana, Anna: 2 articles (10/2009 - 05/2002)
6. Camussi, Giovanni: 2 articles (09/2003 - 08/2002)
7. Dos Santos, Lívia Caires: 1 article (01/2012)
8. Bachi, André Luis Lacerda: 1 article (01/2012)
9. Jancar, Sônia: 1 article (01/2012)
10. Nonogaki, Suely: 1 article (01/2012)

Related Diseases

1. Ischemia
2. Pancreatitis
3. Body Weight (Weight, Body)
01/01/2012 - "Animals received the PAFR antagonists, WEB2170 or PCA4248 (5 mg/kg body weight) or vehicle, by peritumoral daily injection for 5 days. "
01/01/1996 - "In another 5 rabbits, the same amount of labelled CS was instilled by tracheal infusion within 5 min. A third group of 5 animals received 3 mg/kg body weight of the PAF antagonist WEB 2170 before CS bolus instillation. "
12/01/1994 - "WEB 2170 significantly improved inulin and PAH clearances at 36 weeks (inulin clearance: Nx, 182 +/- 28 microliters/min/100 gm body weight; Nx plus WEB, 284 +/- 19 microliters/min/100 gm body weight; p < 0.05; PAH clearance: Nx, 718 +/- 85 microliters/min/100 gm body weight; Nx plus WEB, 1215 +/- 103 microliters/min/100 gm body weight; p < 0.05). "
02/01/1993 - "The administration of two structurally unrelated platelet-activating factor-receptor antagonists (SDZ 63-675, 5 mg/kg body weight, and WEB 2170, 5 mg/kg body weight) before reperfusion significantly reduced the accumulation of PMN, as well as the hemodynamic alterations and the size of necrotic area. "
07/01/1993 - "On the basis of the fact that oxygen radical-catalyzed peroxidation of phospholipids results in the generation of fragments with short sn2 residues, which besides authentic platelet-activating factor (PAF), activate the receptor for PAF on leukocytes and thereby induce leukocyte adhesion, we asked whether pretreatment of hamsters with a specific PAF receptor antagonist (WEB2170; 1 mg/kg of body weight IV, 10 minutes before oxLDL) attenuates leukocyte adhesion after injection of oxLDL (4 mg/kg of body weight IV, oxidized by 7.5 mumol/L Cu2+ for 18 hours at 37 degrees C). "
4. Edema
5. Anaphylaxis (Anaphylactic Shock)

Related Drugs and Biologics

1. Platelet Activating Factor
2. Antigens
3. Evans Blue (Blue, Evans)
4. Caerulein (Ceruletide)
5. Peroxidase (Myeloperoxidase)
6. Inulin
7. Calcium
8. bepafant
9. platelet activating factor receptor
10. NADP (NADPH)

Related Therapies and Procedures

1. Liver Transplantation
2. Ligation
3. Subcutaneous Injections
4. Intravenous Injections
5. Oral Administration