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2- (4- hydroxy- 3,5- dimethylphenyl)- 5- methoxy- 3- methylindole

structure given in first source

Also Known As:

TZI 41127; TZI-41127; Phenol, 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole: 3

Related Diseases

1.	Pleurisy (Pleuritis) 06/18/1991 - "Effects of TZI-41127, a novel selective 5-lipoxygenase inhibitor, on A23187-induced pleurisy in rats." 06/18/1991 - "These results suggest that: (1) A23187-induced pleurisy is an convenient in vivo model for studying drug effects on 5-lipoxygenase and cyclooxygenase activities and (2) TZI-41127 is an orally active and comparatively selective inhibitor of 5-lipoxygenase activity."
2.	Inflammation (Inflammations) 09/01/1994 - "In the present investigation, the effects of selective inhibitors of 5-lipoxygenase (5-LO), zileuton and TZI-41127, E-6080, AA-861 and antagonists of leukotriene B4 (LTB4) receptors, SC-41930, and SC-51146 and a selective cyclooxygenase inhibitor, indomethacin, were examined in TPA-induced acute mouse dermal inflammation. "
3.	Infarction (Infarctions) 02/01/1990 - "The infarct size induced by LAD occlusion in rats was also reduced by the pretreatment with TZI-41127. "

Related Drugs and Biologics

1.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
2.	Leukotriene B4 Receptors (Leukotriene B4 Receptor)
3.	Cyclooxygenase Inhibitors
4.	Lipoxygenase Inhibitors
5.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.	Leukotriene B4
7.	Indomethacin (Indometacin)
8.	7- (3- (2- (cyclopropylmethyl)- 3- methoxy- 4- ((methylamino)carbonyl)phenoxy)propoxy)- 3,4- dihydro- 8- propyl- 2H- 1- benzopyran- 2- propanoic acid
9.	E 6080
10.	zileuton (Zyflo)