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sulfinosine

structure given in first source

Also Known As:

2-amino-9-beta--ribofuranosylpurine-6-sulfinamide; 9H-Purine-6-sulfinamide, 2-amino-9-beta-D-ribofuranosyl-

Networked: 8 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        sulfinosine: 8
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - sulfinosine: 8

Experts

1.	Ruzdijić, Sabera: 3 articles (04/2009 - 08/2002)
2.	Rakić, Ljubisav: 2 articles (01/2013 - 01/2006)
3.	Pesić, Milica: 2 articles (04/2009 - 01/2006)
4.	Rakić, Ljubisa: 2 articles (04/2009 - 08/2002)
5.	Kanazir, Selma: 2 articles (01/2006 - 08/2002)
6.	Dačević, Mirjana: 1 article (01/2013)
7.	Isaković, Aleksandra: 1 article (01/2013)
8.	Isaković, Andelka M: 1 article (01/2013)
9.	Milošević, Zorica: 1 article (01/2013)
10.	Pešić, Milica: 1 article (01/2013)

Related Diseases

1.	Leukemia L1210 05/01/1990 - "Sulfinosine penetrated the central nervous system more readily than did 6TGR and, when given repeatedly, was much more effective in the treatment of L1210 leukemia, being curative for some mice. " 01/01/1990 - "Sulfenosine (8b) at 22 mg/kg per day X 1 showed a T/C of 170, whereas sulfinosine (9b) at 173 mg/kg per day X 1 showed a T/C of 167 against L1210 leukemia. "
2.	Neuroblastoma 01/01/2006 - "The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro." 01/01/2006 - "To identify purine analogs that could be effective in treating neuroblastomas, we tested the anticancer properties of sulfinosine, 8-Cl-cAMP and 8-Cl-adenosine in the SK-N-SH cell line. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/01/2009 - "A resistant non-small cell lung carcinoma cell line-NSCLC (NCI-H460/R) was established in order to investigate the potential of sulfinosine (SF) to overcome multidrug resistance (MDR). " 04/01/2009 - "Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R)." 07/01/2008 - "Our results show that sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC), especially in combination despite the presence of a mutated p53 gene." 07/01/2008 - "We tested the potential of sulfinosine and curcumin, alone and in combination, for modulating MDR in the human resistant, non-small cell lung carcinoma cell line (NCI-H460/R). " 08/01/2002 - "In the present study, we used the novel purine ribunocleoside sulfinosine and evaluated its antiproliferative and apoptotic outcome on the non-small cell lung carcinoma cell line (NSCLC) and the small cell lung carcinoma cell line (SCLC). "
4.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 08/01/2002 - "In the present study, we used the novel purine ribunocleoside sulfinosine and evaluated its antiproliferative and apoptotic outcome on the non-small cell lung carcinoma cell line (NSCLC) and the small cell lung carcinoma cell line (SCLC). "
5.	Lung Neoplasms (Lung Cancer) 08/01/2002 - "From these results, we concluded that sulfinosine may act as an anticancer agent and further studies may prove its efficacy in lung cancer cells. "

Related Drugs and Biologics

1.	purine
2.	8-chloro-cyclic adenosine monophosphate
3.	Antineoplastic Agents (Antineoplastics)
4.	Doxorubicin (Adriamycin)
5.	Curcumin
6.	Paclitaxel (Taxol)
7.	Mercaptopurine (6 Mercaptopurine)
8.	Vincristine (Oncovin)
9.	Thioguanine (Tioguanine)
10.	Thalidomide (Thalomid)