L 663581

structure given in first source; partial agonist at the benzodiazepine receptor

Also Known As:

7-chloro-5,6-dihydro-5-methyl-6-oxo-3-(5-isopropyl-1,2,4-oxadiazol-3-yl)-4H-imidazo(1,5a)(1,4)benzodiazepine; FG 8205; FG-8205; L-663581; 6H-Imidazo(1,5-a)(1,4)benzodiazepin-6-one, 7-chloro-4,5-dihydro-5-methyl-3-(5-(1-methylethyl)-1,2,4-oxadiazol-3-yl)-

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        L 663581: 1

Related Diseases

1.	Seizures (Absence Seizure) 11/01/1990 - "However, even high doses of FG 8205 (50 mg kg-1) did not protect against seizures induced by electroshock. " 11/01/1990 - "4. In anticonvulsant studies, the ED50 doses of FG 8205 and diazepam needed to antagonize seizures induced by pentylenetetrazol (PTZ) or by sound in audiogenic seizure prone mice were similar with values of 0.2-0.3 mg kg-1, i.p. " 11/01/1990 - "6. While the potentiation by FG 8205 of the response to isoguvacine in the rat hippocampal slice and the anxiolytic-like effects of the compound in both rats and primates were reversed by the benzodiazepine receptor antagonist, flumazenil, high doses of the antagonist were able only marginally to block the protective effects of FG 8205 against seizures induced by PTZ in the mouse. "
2.	Ataxia (Dyssynergia) 11/01/1990 - "However, measures of sedation and ataxia (as measured by rotarod in the mouse, climbing behaviour in the rat, and by scoring arousal and co-ordination in primates) were slight and only transiently affected by FG 8205, and FG 8205 significantly antagonized the rotarod performance deficit induced by diazepam in the mouse. "

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	GABA-A Receptors (GABA(A) Receptor)
3.	Flumazenil (Romazicon)
4.	isoguvacine
5.	Pentylenetetrazole (Metrazol)
6.	Diazepam (Valium)
7.	Anticonvulsants (Antiepileptic Drugs)