hirsuteine

structure given in first source; RN given refers to parent cpd; isolated from Uncaria rhynchophylla

Also Known As:

hirsuteine hydrochloride; hirsuteine, (3beta,16E)-isomer; hirsuteine, (R-(R*,R*))-tartrate (1:1) salt

Networked: 8 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - hirsuteine: 8

Experts

1.	Gao, Shan: 1 article (11/2022)
2.	Guo, Tingting: 1 article (11/2022)
3.	Hu, Gaoyong: 1 article (11/2022)
4.	Jia, Wenqing: 1 article (11/2022)
5.	Kong, Dexin: 1 article (11/2022)
6.	Lang, Xiaona: 1 article (11/2022)
7.	Luo, Shuyu: 1 article (11/2022)
8.	Qiu, Yuling: 1 article (11/2022)
9.	Ren, Zehao: 1 article (11/2022)
10.	Yu, Haiyang: 1 article (11/2022)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 05/31/2023 - "Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53." 05/31/2023 - "The present study aimed to explore the anticancer activity of hirsuteine (HST), an indole alkaloid from the traditional Chinese herbal medicine Uncaria rhynchophylla, against colorectal cancer (CRC) and the underlining mechanism. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "The aim of the present study was to examine the antiproliferative ability of hirsuteine using human breast cancer MDA-MB-453 cells and to determine the underlying molecular mechanism involved in its therapeutic efficacy. " 01/01/2023 - "Effects of hirsuteine on MDA-MB-453 breast cancer cell proliferation."
3.	Hypertension (High Blood Pressure) 01/01/2023 - "Hirsuteine is extracted from Uncaria rhynchophylla, the bark of which has traditionally been used to treat hypertension, cancer, convulsions, hemorrhage, auto-immune disorders, and other ailments. " 11/30/2021 - "Further, the potential vasodilative compounds which include corynoxeine, isocorynoxeine, isorhynchophylline, rhynchophylline, hirsuteine and hirsutine were screened through the correlation analysis between metabolites and anti-hypertension activities. " 01/01/2020 - "Hirsutine and hirsuteine are the main pharmacological activity ingredients of Uncaria rhynchophylla (UR), playing an important role in treating mental and cardiovascular diseases, such as Alzheimer's disease, hypertension, Parkinson's disease, potential anti-cancer activities and so on. "
4.	Neoplasms (Cancer) 01/01/2023 - "Thus, hirsuteine suppressed MDA-MB-453 cancer cell proliferation by inducing cell cycle arrest and promoting apoptosis." 01/01/2023 - "Hirsuteine is extracted from Uncaria rhynchophylla, the bark of which has traditionally been used to treat hypertension, cancer, convulsions, hemorrhage, auto-immune disorders, and other ailments. " 01/01/2020 - "Hirsutine and hirsuteine are the main pharmacological activity ingredients of Uncaria rhynchophylla (UR), playing an important role in treating mental and cardiovascular diseases, such as Alzheimer's disease, hypertension, Parkinson's disease, potential anti-cancer activities and so on. "
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/01/2022 - "Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1."

Related Drugs and Biologics

1.	Indole Alkaloids
2.	hirsutine
3.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
4.	Nicotine
5.	Dopamine (Intropin)
6.	Alkaloids
7.	corynoxeine
8.	rhyncophylline
9.	sphingosine kinase

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)