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1- (1,3- dihydroxy- 2- propoxymethyl)- 5,6- tetramethyleneuracil
structure given in first source
Also Known As:
DHPTU
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidinones: 71
Uracil: 1493
1-(1,3-dihydroxy-2-propoxymethyl)-5,6-tetramethyleneuracil: 1
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
11/01/1989 - "
Growth inhibition of Kirkman-Robbins hepatoma by 1-(1,3-dihydroxy-2-propoxymethyl)-5,6-tetramethyleneuracil and possible mechanism of its biological activity.
"
11/01/1989 - "
Since DCF which prevented FA deamination to FB (which is not an inhibitor of the mentioned enzyme) reduces DHPTU-induced changes in activity of dN kinases and dTMP kinase in hepatoma cells, the cytostatic activity of DHPTU seems to be connected to an enzyme which releases TU from DHPTU.
"
Related Drugs and Biologics
1.
Cytostatic Agents
2.
Phosphotransferases (Kinase)
3.
Enzymes
4.
dTMP kinase