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N,N-dimethylcarbamoylmethyl alpha,2- dimethyl- 5H- 1- benzopyrano(2,3- b)pyridine- 7- acetate
Also Known As:
N,N-DCDBPA; Y 23023; Y-23023
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate: 1
Pyridines: 88
N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate: 1
Related Diseases
1.
Chronic Pain
08/01/1995 - "
The analgesic and anti-inflammatory activities of Y-23023, a new nonsteroidal analgesic and anti-inflammatory compound, were investigated in acute, subacute and chronic pain models in rats.
"
2.
Pain (Aches)
08/01/1995 - "
Therefore, Y-23023 would be regarded to show predominantly strong analgesic activity in acute and subacute pain when compared with reference drugs.
"
08/01/1995 - "
Y-23023 (0.3-10 mg/kg, p.o.) also had a potent inhibitory effect on the silver nitrate-induced arthritic pain.
"
08/01/1995 - "
In suppressing acute and subacute pain, Y-23023 was more potent than diclofenac sodium, indomethacin and loxoprofen sodium.
"
3.
Hyperalgesia
08/01/1995 - "
In the carrageenin paw edema test, Y-23023 (0.3-3 mg/kg, p.o.) dose-dependently inhibited hyperalgesia assessed by the Randall-Selitto method and paw edema.
"
08/01/1995 - "
The analgesic and anti-inflammatory activities of Y-23023 (0.1-1 mg/kg/day, p.o.) on the adjuvant-induced hyperalgesia and the paw swelling were nearly equipotent to diclofenac sodium and indomethacin, but were more potent than loxoprofen sodium.
"
4.
Edema (Dropsy)
08/01/1995 - "
Y-23023 (1 mg/kg, p.o.), when administered at 2 hr after carrageenin injection, significantly elevated the reduced pain threshold without affecting paw edema.
"
08/01/1995 - "
In the carrageenin paw edema test, Y-23023 (0.3-3 mg/kg, p.o.) dose-dependently inhibited hyperalgesia assessed by the Randall-Selitto method and paw edema.
"
Related Drugs and Biologics
1.
Sodium
2.
Silver Nitrate
3.
Indomethacin (Indometacin)
4.
Diclofenac (SR 38)
5.
Carrageenan
6.
Analgesics (Analgesic Drugs)
7.
loxoprofen (CS 600)