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butamidine

RN refers to HCl; structure in first source

Also Known As:

1,4-bis(4-amidinophenoxy)butane

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Benzamidines: 5
    - Pentamidine: 1147
      - butamidine: 4

Related Diseases

1.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 08/01/1994 - "In terms of structure-activity relationships, the AT-specific recognition of DNA by this series of butamidine derivatives cannot be directly correlated with their potencies against Pneumocystis carinii pneumonia." 01/01/1993 - "Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents." 08/01/1994 - "Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine."
2.	Keratitis 02/01/1995 - "Because some Acanthamoeba strains have been reported to be resistant to propamidine and propamidine was found to be only weakly cysticidal, superior homologs such as butamidine, pentamidine, hexamidine, heptamidine, octamidine, and nonamidine were tested for their amoebicidal effects on two Acanthamoeba strains isolated from patients with keratitis. "
3.	Infections 04/01/1990 - "Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the rat model of infection. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 08/01/1994 - "(II) have been used to investigate the sequence selectivity in binding to DNA of pentamidine and four butamidine analogues active against the Pneumocystis carinii pathogen, which afflicts patients with acquired immunodeficiency syndrome. "

Related Drugs and Biologics

1.	Pentamidine (NebuPent)
2.	butamidine
3.	DNA (Deoxyribonucleic Acid)
4.	1,3- bis(4- amidino- 2- methoxyphenoxy)propane
5.	hexamidine
6.	propamidine